Cipriano P R, Sacks A H, Reitz B A
Circulation. 1980 Jul;62(1):61-6. doi: 10.1161/01.cir.62.1.61.
A mechanical model of a branched coronary artery with a graft bypassing an 80% stenosis of one branch was used to study the reduction in coronary flow due to stenosis of the bypass graft. Flow Reynolds number and ratio of aortic pressure to dynamic pressure were matched to the living system. Changes in coronary flow were measured for a range of stenoses (0-100%) of bypass grafts with graft-to-coronary-diameter ratios of 4:1, 3:1, 2:1 and 1:1 for conditions that simulated rest and exercise. The results of these studies indicate that: 1) marked stenosis of bypass grafts is needed to decrease coronary flow in the resting state, and even moderate stenosis will decrease flow during exercise when the diameter of the bypass is large relative to the coronary artery; 2) coronary flow is decreased with mild stenosis for bypass grafts of the same diameter as the coronary artery; and 3) a marked decrease in flow due to stenosis of a bypass graft occurs only when the diameter of a stenosis in a graft is less than the diameter of the coronary artery.
采用一个带有旁路移植物的分支冠状动脉力学模型，该旁路绕过一个分支80%的狭窄部位，以研究旁路移植物狭窄导致的冠状动脉血流减少情况。血流雷诺数以及主动脉压与动压之比与活体系统相匹配。针对模拟静息和运动状态的情况，测量了旁路移植物狭窄程度（0 - 100%）范围、移植物与冠状动脉直径比为4:1、3:1、2:1和1:1时冠状动脉血流的变化。这些研究结果表明：1）在静息状态下，需要旁路移植物显著狭窄才能降低冠状动脉血流，并且当旁路直径相对于冠状动脉较大时，即使是中度狭窄在运动时也会降低血流；2）对于与冠状动脉直径相同的旁路移植物，轻度狭窄会使冠状动脉血流减少；3）仅当移植物中狭窄部位的直径小于冠状动脉直径时，旁路移植物狭窄才会导致血流显著减少。
