Salar G, Iob I, Mingrino S
Neurology. 1980 Jun;30(6):663-5. doi: 10.1212/wnl.30.6.663.
Percutaneous electrostimulation, acupuncture, and direct stimulation of the central nervous system are supposed to be capable of reducing painful sensation by releasing enkephalins and endorphins. We treated six volunteers with electrotherapy, obtaining in all cases a clear reduction of the pain induced by electric stimulation of the median nerve at the wrist. During the treatment, the administration of naloxone, an antagonist of morphine, in four subjects provoked a short but clear and immediate return of pain. In the other two cases, the drug provoked a further decrease of the painful sensation. During electro-stimulation in all patients, the somatosensory evoked potentials showed a statistically significant decrease. In the four "naloxone-responsive" subjects, the cortical evoked responses returned to basal amplitude after naloxone. In the two patients with a clinically paradoxic response, nonsignificant modification in the cortical evoked potentials was noted.
经皮电刺激、针灸以及直接刺激中枢神经系统被认为能够通过释放脑啡肽和内啡肽来减轻疼痛感觉。我们对六名志愿者进行了电疗法治疗，在所有病例中均明显减轻了腕部正中神经电刺激所诱发的疼痛。在治疗过程中，给四名受试者注射吗啡拮抗剂纳洛酮后，疼痛短暂但明显且立即复发。在另外两例中，该药物使疼痛感觉进一步减轻。在所有患者进行电刺激期间，体感诱发电位显示出有统计学意义的下降。在四名“对纳洛酮有反应”的受试者中，注射纳洛酮后皮质诱发电位恢复到基础幅度。在两名出现临床矛盾反应的患者中，皮质诱发电位未见明显改变。
