Belfort R, Mendes N F
Br J Ophthalmol. 1980 Mar;64(3):217-9. doi: 10.1136/bjo.64.3.217.
The presence and localisation of T and B lymphocytes in biopsy specimens of human conjunctiva and lacrimal gland from 34 patients were studied in frozen sections. Eighteen patients had follicular conjunctivitis, 13 patients had Sjögren's syndrome, and 3 were normal. All cases of follicular conjunctivitis showed a similar picture. B cells were in higher number than T cells, but both types of lymphocytes were present in the infiltrates. In the developed follicles T cells occupied the periphery and B cells the central part of the infiltrates. In patients with Sjögren's syndrome the conjunctival biopsies showed a higher number of B lymphocytes. The number of T cells was higher in the lesions from Sjögren's syndrome than in cases of follicular conjunctivitis. The infiltrate in lacrimal gland biopsies showed T cells which were scattered while B cells were more numerous and formed clusters close to vessels. Normal conjunctiva and lacrimal gland showed no adherence of either sheep erythrocytes or human erythrocytes sensitised with antibody and complement.
对34例患者的人结膜和泪腺活检标本进行冷冻切片，研究T和B淋巴细胞的存在及定位。18例患者患有滤泡性结膜炎，13例患者患有干燥综合征，3例正常。所有滤泡性结膜炎病例表现相似。B细胞数量多于T细胞，但两种淋巴细胞均存在于浸润物中。在成熟滤泡中，T细胞占据浸润物周边，B细胞占据中央部分。干燥综合征患者的结膜活检显示B淋巴细胞数量较多。干燥综合征病变中的T细胞数量高于滤泡性结膜炎病例。泪腺活检中的浸润物显示T细胞呈散在分布，而B细胞数量更多，在血管附近形成簇状。正常结膜和泪腺对用抗体和补体致敏的绵羊红细胞或人红细胞均无黏附现象。
