Regan B A, Hanifin J W, Landes M J, Osterberg A C, Patel G J, Ridge D N, Sloboda A E, Lang S A
J Pharm Sci. 1980 Jul;69(7):789-93. doi: 10.1002/jps.2600690711.
Several formamidine and acetamidine derivatives prepared from 3-amino-1,2,4-benzotriazine and 3-amino-1,2,4-benzotriazine-1-oxide displayed an aspirin-like anti-inflammatory and analgesic profile. The test systems include adjuvant-induced arthritis in rats, carrageenan-induced edema in rats, UV-induced erythema in guinea pigs, the analgesic gait test, the antipyretic test, and GI ulcer studies.
由3-氨基-1,2,4-苯并三嗪和3-氨基-1,2,4-苯并三嗪-1-氧化物制备的几种甲脒和乙脒衍生物表现出类似阿司匹林的抗炎和镇痛特性。测试系统包括大鼠佐剂性关节炎、大鼠角叉菜胶性水肿、豚鼠紫外线诱导的红斑、镇痛步态试验、解热试验和胃肠道溃疡研究。
