对AKR小鼠自然发生的鼠白血病病毒感染的定量研究。
Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.
作者信息
Rowe W P, Pincus T
出版信息
J Exp Med. 1972 Feb 1;135(2):429-36. doi: 10.1084/jem.135.2.429.
Abstract
Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice.
摘要
对不同年龄的AKR小鼠体内鼠白血病病毒的器官分布进行了定量研究。感染性病毒在出生前不久或出生后不久首次出现，此后在所有小鼠中持续存在。子宫和骨骼中的感染性滴度最高，脾脏略低。正常胸腺中的病毒滴度相对较低，但随着胸腺淋巴瘤的发展显著增加。病毒血症水平在出生后第1个月后下降，但在淋巴瘤小鼠中急剧上升。
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