• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.对AKR小鼠自然发生的鼠白血病病毒感染的定量研究。
J Exp Med. 1972 Feb 1;135(2):429-36. doi: 10.1084/jem.135.2.429.
2
A discrepancy in XC and oncogenicity assays for murine leukemia virus in AKR mice.AKR小鼠中鼠白血病病毒XC和致癌性检测的差异。
Cancer Res. 1977 Mar;37(3):726-30.
3
Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.AKR小鼠白血病前期晚期鼠白血病病毒抗原表达的变化及嗜异性病毒的产生
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680-4. doi: 10.1073/pnas.73.12.4680.
4
Suppressive effects of the bacterial immunostimulant OK-432 on the incidence of spontaneous thymic lymphoma in AKR mice.细菌免疫刺激剂OK-432对AKR小鼠自发性胸腺淋巴瘤发病率的抑制作用。
Zentralbl Bakteriol. 1989 Sep;271(3):330-8. doi: 10.1016/s0934-8840(89)80031-3.
5
Type-C RNA viruses and leukemogenesis: relation of type-C virus infectivity and leukemogenesis induced by nitrosourea compounds in mice.C型RNA病毒与白血病发生：C型病毒感染性与亚硝基脲化合物诱导小鼠白血病发生的关系。
Gan. 1976 Jun;67(3):389-98.
6
DEAE-dextran enhancement of in vivo infection with murine leukemia virus.二乙氨基乙基葡聚糖增强小鼠白血病病毒的体内感染
Arch Gesamte Virusforsch. 1973;40(3):307-10. doi: 10.1007/BF01242550.
7
A positive difference in nature of envelopes of thymus- and uterus-derived leukemia viruses of AKR mice.AKR小鼠胸腺和子宫衍生白血病病毒包膜性质的阳性差异。
Can J Microbiol. 1977 Mar;23(3):354-7. doi: 10.1139/m77-052.
8
Spontaneous leukemia viruses: lymphomagenic ecotropic viruses of AKR mice.自发性白血病病毒：AKR小鼠的致淋巴瘤嗜亲性病毒。
J Natl Cancer Inst. 1982 Nov;69(5):1077-82.
9
Differences in the properties of cytoplasmic particles and in the expression of virus-specific information in the thymus of normal and lymphomatous AKR mice.正常和淋巴瘤性AKR小鼠胸腺中细胞质颗粒特性及病毒特异性信息表达的差异。
Cancer Res. 1978 Aug;38(8):2473-9.
10
Loss of antigenic epitopes as the result of env gene recombination in retrovirus-induced leukemia in immunocompetent mice.在免疫活性小鼠中，逆转录病毒诱导的白血病中env基因重组导致抗原表位丧失。
Virology. 1993 Feb;192(2):587-95. doi: 10.1006/viro.1993.1075.

引用本文的文献

1
Endogenous Retroviruses in Host-Virus Coevolution: From Genomic Domestication to Functional Innovation.宿主-病毒共同进化中的内源性逆转录病毒：从基因组驯化到功能创新
Genes (Basel). 2025 Aug 15;16(8):964. doi: 10.3390/genes16080964.
2
Viral component of the human genome.人类基因组的病毒成分。
Mol Biol. 2017;51(2):205-215. doi: 10.1134/S0026893317020066. Epub 2017 May 9.
3
Intact Viral Particle Counts Measured by Flow Virometry Provide Insight into the Infectivity and Genome Packaging Efficiency of Moloney Murine Leukemia Virus.流式病毒仪检测完整病毒颗粒计数可深入了解莫洛尼鼠白血病病毒的感染性和基因组包装效率。
J Virol. 2020 Jan 6;94(2). doi: 10.1128/JVI.01600-19.
4
Mouse APOBEC3 expression in NIH 3T3 cells mediates hypermutation of AKV murine leukemia virus.NIH 3T3 细胞中的小鼠 APOBEC3 表达介导 AKV 鼠白血病病毒的超突变。
Virology. 2018 May;518:377-384. doi: 10.1016/j.virol.2018.03.014. Epub 2018 Mar 30.
5
Origins of the endogenous and infectious laboratory mouse gammaretroviruses.内源性和感染性实验室小鼠γ逆转录病毒的起源。
Viruses. 2014 Dec 26;7(1):1-26. doi: 10.3390/v7010001.
6
Identification of a group of Mus dunni endogenous virus-like endogenous retroviruses from the C57BL/6J mouse genome: proviral genomes, strain distribution, expression characteristics, and genomic integration profile.从 C57BL/6J 鼠基因组中鉴定出一群 Mus dunni 内源性病毒样内源性逆转录病毒：前病毒基因组、株分布、表达特征和基因组整合图谱。
Chromosome Res. 2012 Oct;20(7):859-74. doi: 10.1007/s10577-012-9322-z. Epub 2012 Nov 30.
7
RNAi in the regulation of mammalian viral infections.RNAi 在调控哺乳动物病毒感染中的作用。
BMC Biol. 2012 Jun 26;10:58. doi: 10.1186/1741-7007-10-58.
8
The mouse "xenotropic" gammaretroviruses and their XPR1 receptor.鼠“异嗜性”γ逆转录病毒及其 XPR1 受体。
Retrovirology. 2010 Nov 30;7:101. doi: 10.1186/1742-4690-7-101.
9
The discovery of endogenous retroviruses.内源性逆转录病毒的发现。
Retrovirology. 2006 Oct 3;3:67. doi: 10.1186/1742-4690-3-67.
10
Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.鼠白血病病毒Gag多聚蛋白与KIF4（一种基于微管的驱动蛋白）的结合。
J Virol. 1998 Aug;72(8):6898-901. doi: 10.1128/JVI.72.8.6898-6901.1998.

本文引用的文献

1
"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.在婴儿期接种AK白血病提取物或AK胚胎后，C3H小鼠中发生的“自发性”白血病。
Proc Soc Exp Biol Med. 1951 Jan;76(1):27-32.
2
The R.I.L. strain of mice: its relation to the leukemic AK strain and AKR substrains.R.I.L.品系小鼠：其与白血病AK品系及AKR亚品系的关系。
J Natl Cancer Inst. 1954 Aug;15(1):161-76.
3
Wild-type Gross leukemia virus. I. Soluble antigen (GSA) in the plasma and tissues of infected mice.野生型格罗斯白血病病毒。I. 感染小鼠血浆和组织中的可溶性抗原（GSA）。
J Natl Cancer Inst. 1968 Jul;41(1):89-96.
4
A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses.一个影响对鼠白血病病毒感染抗性的主要基因位点。I. 自然发生病毒的组织培养研究
J Exp Med. 1971 Jun 1;133(6):1219-33. doi: 10.1084/jem.133.6.1219.
5
Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.小鼠胚胎细胞培养中小鼠白血病病毒的宿主范围限制
J Virol. 1970 Feb;5(2):221-5. doi: 10.1128/JVI.5.2.221-225.1970.
6
Formation of virus-like particles by bone cells in mice with a high incidence of spontaneous leukemia.在自发性白血病发病率高的小鼠中，骨细胞形成病毒样颗粒。
Science. 1970 May 1;168(3931):588-9. doi: 10.1126/science.168.3931.588.
7
Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture.在组织培养中分离鼠白血病病毒组的天然存在病毒。
J Virol. 1969 Feb;3(2):126-32. doi: 10.1128/JVI.3.2.126-132.1969.
8
Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture.混合培养细胞致病性：一种检测小鼠白血病病毒在组织培养中生长情况的新试验。
Proc Natl Acad Sci U S A. 1969 Jul;63(3):753-8. doi: 10.1073/pnas.63.3.753.
9
Plaque assay techniques for murine leukemia viruses.小鼠白血病病毒的噬斑测定技术
Virology. 1970 Dec;42(4):1136-9. doi: 10.1016/0042-6822(70)90362-4.

对AKR小鼠自然发生的鼠白血病病毒感染的定量研究。

Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.

作者信息

Rowe W P, Pincus T

出版信息

J Exp Med. 1972 Feb 1;135(2):429-36. doi: 10.1084/jem.135.2.429.

DOI:10.1084/jem.135.2.429
PMID:4334098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180520/
Abstract

Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice.

摘要

对不同年龄的AKR小鼠体内鼠白血病病毒的器官分布进行了定量研究。感染性病毒在出生前不久或出生后不久首次出现，此后在所有小鼠中持续存在。子宫和骨骼中的感染性滴度最高，脾脏略低。正常胸腺中的病毒滴度相对较低，但随着胸腺淋巴瘤的发展显著增加。病毒血症水平在出生后第1个月后下降，但在淋巴瘤小鼠中急剧上升。