Yamamoto M, Murayama S
Pharmacology. 1980;20(6):310-5. doi: 10.1159/000137386.
Effects of L-5-hydroxytryptophan (L-5HTP), an active precursor of 5-hydroxytryptamine (5-HT), and electrical stimulation of the dorsal raphe nucleus were observed on the activity of the caudate nucleus in cats with electroencephalographic and evoked potential studies. In an electroencephalographic study, thecaudate spindle and the VA spindle, recorded in the cerebral cortex and induced by electrical stimulation of the caudate nucleus and the anterior ventral nucleus, respectively, were inhibited by L-5HTP. The inhibitory effect of L-5HTP on the caudate spindle was stronger than that on the VA spindle. These inhibitory effects of L-5HTP were observed when L-5HTP showed synchronization on spontaneous EEG and no effect on the duration of the cortical after discharge. In the evoked potential study, both electrical stimulation of the dorsal raphe nucleus and exogenous L-5HTP inhibited the activity of the potentials in the caudate nucleus induced by electrical stimulation of the radial nerve. These results suggest that the neuronal activity of the caudate nucleus is inhibited by the serotonergic system.
通过脑电图和诱发电位研究，观察了5-羟色胺（5-HT）的活性前体L-5-羟色氨酸（L-5HTP）以及中缝背核的电刺激对猫尾状核活动的影响。在脑电图研究中，L-5HTP抑制了分别由尾状核和前腹侧核的电刺激所诱发、记录于大脑皮层的尾状核纺锤波和VA纺锤波。L-5HTP对尾状核纺锤波的抑制作用强于对VA纺锤波的抑制作用。当L-5HTP与自发脑电图显示同步且对皮层放电后时程无影响时，观察到了L-5HTP的这些抑制作用。在诱发电位研究中，中缝背核的电刺激和外源性L-5HTP均抑制了由桡神经电刺激所诱发的尾状核电位活动。这些结果提示，5-羟色胺能系统抑制尾状核的神经元活动。
