Robinson W A, Entringer M A, Huber J, Gupta R
Adv Exp Med Biol. 1980;127:281-91. doi: 10.1007/978-1-4757-0259-0_21.
Studies have been cazrried out to determine the in vivo and in vitro effects of lithium carbonate in various neutropenic disorders. Addition of lithium to culture of bone marrow from patients with a variety of neutropenic disorders and ANLL in which normal or elevated serum and/or urinary CSA levels were present did not enhance granulocyte colony formation. Administration of lithium carbonate to patients with Felty's syndrome, in which serum and urinary CSA levels are reduced, enhanced peripheral blood neutrophil levels and serum and urinary CSA values. Lithium administration appears to be most beneficial in neutropenic patients in whom it can be demonstrated that CSA production is reduced.
已经开展了多项研究，以确定碳酸锂在各种中性粒细胞减少症中的体内和体外作用。在患有各种中性粒细胞减少症和急性非淋巴细胞白血病（ANLL）的患者的骨髓培养物中添加锂，这些患者的血清和/或尿中CSA水平正常或升高，结果并未增强粒细胞集落形成。对于血清和尿中CSA水平降低的费尔蒂综合征患者给予碳酸锂，可提高外周血中性粒细胞水平以及血清和尿中CSA值。锂治疗似乎对能够证明CSA生成减少的中性粒细胞减少症患者最有益。
