Blankstein J, Fujieda K, Reyes F I, Faiman C, Winter J S
Am J Obstet Gynecol. 1980 Aug 1;137(7):781-4. doi: 10.1016/0002-9378(80)90885-6.
Concentrations of unconjugated cortisol, 11-desoxycortisol, and 21-desoxycortisol were measured by radioimmunoassay in amniotic fluid throughout gestation. Cortisol levels rose from a median of 6.5 nanograms per milliliter prior to 20 weeks to 13.9 ng/ml at 28 to 37 weeks. Median levels of 11-desoxycortisol and 21-desoxycortisol were 2.6 ng/ml and 0.21 ng/ml, respectively, and did not change with advancing gestation. These normal values provide a basis for the application of assays of 11-desoxycortisol and 21-desoxycortisol in amniotic fluid in the prenatal diagnosis of congenital adrenal hyperplasia.
在整个孕期通过放射免疫分析法测定羊水中共轭皮质醇、11-脱氧皮质醇和21-脱氧皮质醇的浓度。皮质醇水平从妊娠20周前的中位数6.5纳克/毫升升至28至37周时的13.9纳克/毫升。11-脱氧皮质醇和21-脱氧皮质醇的中位数水平分别为2.6纳克/毫升和0.21纳克/毫升，且不随孕周增加而变化。这些正常值为羊水11-脱氧皮质醇和21-脱氧皮质醇检测在先天性肾上腺皮质增生症产前诊断中的应用提供了依据。
