Nakano M M, Ogawara H
J Antibiot (Tokyo). 1980 Apr;33(4):420-5. doi: 10.7164/antibiotics.33.420.
Arg mutants, isolated from Streptomyces lavendulae at unusually high frequencies, showed several phenotypic characteristics. The characteristics common to all arg mutants include: (1) repression of beta-lactamase production, (2) inhibition of aerial mycelium formation, (3) development of acid pH, (4) low saturation density of growth in liquid culture, (5) a decrease in antibiotic production, (6) an increase in sensitivity to benzylpenicillin and (7) a decrease in production of pigment. These results suggest that the arg mutation concomitantly caused the depression of secondary metabolism in S. lavendulae.
从薰衣草链霉菌中以异常高的频率分离出的精氨酸突变体表现出几种表型特征。所有精氨酸突变体共有的特征包括：（1）β-内酰胺酶产生受到抑制，（2）气生菌丝体形成受到抑制，（3）酸性pH的形成，（4）液体培养中生长的饱和密度低，（5）抗生素产量降低，（6）对苄青霉素的敏感性增加，以及（7）色素产量降低。这些结果表明，精氨酸突变同时导致了薰衣草链霉菌次生代谢的抑制。
