一名13号染色体缺失型视网膜母细胞瘤患者成纤维细胞中姐妹染色单体交换增加（作者译）
[Increased sister-chromatid exchanges in fibroblasts from a del(13)-retinoblastoma patient (author's transl)].
作者信息
Turleau C, Cabanis M O, de Grouchy J
出版信息
Ann Genet. 1980;23(3):169-70.
PMID:6968533
Abstract
Sister-chromatid exchanges were studied in fibroblasts from a child with del(13)-retinoblastoma. The skin biopsy was performed before the clinical onset of the tumor. The observed frequency of SCE, 19.65 per cell, was significantly increased as compared to that of a normal control, 14.68 per cell (t = 3.57, p < 0.001).
摘要
对一名患有13号染色体缺失型视网膜母细胞瘤患儿的成纤维细胞进行了姐妹染色单体交换研究。在肿瘤临床发病前进行了皮肤活检。观察到的姐妹染色单体交换频率为每细胞19.65次，与正常对照（每细胞14.68次）相比显著增加（t = 3.57，p < 0.001）。
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