脂多糖（LPS）对胸腺细胞对PHA反应的影响：品系差异

Effect of lipopolysaccharide (LPS) on the thymocyte response to PHA: strain difference.

作者信息

Mizuguchi J, Kakiuchi T, Nariuchi H, Matuhasi T

出版信息

Immunology. 1980 Oct;41(2):393-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458169/

Abstract

Thymocytes responded well to PHA in terms of [3H]-TdR incorporation if they were precultured in the presence of LPS, whereas fresh thymocytes or thymocytes pre-cultured in the absence of LPS responded poorly to PHA. The PHA response of thymocytes pre-cultured with LPS for several hours was similar to that of fresh spleen cells in the kinetics and dose-response profiles. The effect of LPS was found on thymocytes from BALB/c.Cr, AKR/Jms, and DDD/1 mice, but was not observed on those from C3H/HeJms and C57Bl/6J mice, indicating that there is a strain difference in the PHA responsiveness of LPS-pre-cultured thymocytes. In contrast to thymocytes, the response of spleen cells to PHA was enhanced in both C57Bl/6J and BALB/c.Cr mice by pre-culture with LPS.

摘要

如果胸腺细胞在脂多糖（LPS）存在的情况下进行预培养，那么它们对植物血凝素（PHA）刺激的[3H]-胸腺嘧啶核苷（TdR）掺入反应良好，而新鲜胸腺细胞或在无LPS条件下预培养的胸腺细胞对PHA的反应较差。用LPS预培养数小时的胸腺细胞对PHA的反应在动力学和剂量反应曲线上与新鲜脾细胞相似。在BALB/c.Cr、AKR/Jms和DDD/1小鼠的胸腺细胞中发现了LPS的作用，但在C3H/HeJms和C57Bl/6J小鼠的胸腺细胞中未观察到，这表明LPS预培养的胸腺细胞对PHA的反应性存在品系差异。与胸腺细胞相反，在C57Bl/6J和BALB/c.Cr小鼠中，脾细胞经LPS预培养后对PHA的反应均增强。

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本文引用的文献

1

Cellular recognition in vitro by mouse lymphocytes. Effects of neonatal thymectomy and thymus graft restoration on alloantigen and PHA stimulation of whole and gradient-separated subpopulations of spleen cells.小鼠淋巴细胞的体外细胞识别。新生期胸腺切除及胸腺移植恢复对脾细胞全群体和梯度分离亚群体的同种抗原及PHA刺激的影响。

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Requirement of thymus-dependent lymphocytes for potentiation by adjuvants of antibody formation.胸腺依赖性淋巴细胞对佐剂增强抗体形成的需求。

Nature. 1971 Oct 1;233(5318):330-2. doi: 10.1038/233330a0.

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Immunologic properties of mouse thymus cells: membrane antigen patterns associated with various cell subpopulations.小鼠胸腺细胞的免疫学特性：与各种细胞亚群相关的膜抗原模式。

Cell Immunol. 1973 May;7(2):275-89. doi: 10.1016/0008-8749(73)90250-5.

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Some effects of Escherichia coli endotoxin on the graft-versus-host reaction in mice.大肠杆菌内毒素对小鼠移植物抗宿主反应的某些影响。

Transplantation. 1972 Oct;14(4):432-7.

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Potentiation of helper T cell function in IgE antibody responses by bacterial lipolysaccharide (LPS).细菌脂多糖（LPS）对辅助性T细胞在IgE抗体应答中的功能增强作用。

J Immunol. 1974 Sep;113(3):824-9.

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Specific recognition reactions at the cellular level in mouse lymphoreticular cell subpopulations.

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Cellular site of action of various adjuvants in antibody responses to hapten-carrier conjugates.各种佐剂在对半抗原-载体偶联物抗体应答中的细胞作用位点。

J Immunol. 1973 Nov;111(5):1554-63.

8

Functional heterogeneity of murine lymphoid cells. II. Acquisition of mitogen responsiveness and of theta antigen during the ontogeny of thymocytes and "T" lymphocytes.小鼠淋巴细胞的功能异质性。II. 胸腺细胞和 “T” 淋巴细胞个体发育过程中有丝分裂原反应性和θ抗原的获得。

Cell Immunol. 1972 Aug;4(4):367-80. doi: 10.1016/0008-8749(72)90039-1.

9

Synergism of bacterial lipopolysaccharides and concanavalin A in the activation of thymic lymphocytes.细菌脂多糖与伴刀豆球蛋白A在胸腺淋巴细胞激活中的协同作用。

Cell Immunol. 1975 Jun;17(2):532-41. doi: 10.1016/s0008-8749(75)80057-8.

10

Effects of bacterial lipopolysaccharide on the induction and expression of cell-mediated immunity. I. Depression of the afferent arc.细菌脂多糖对细胞介导免疫诱导和表达的影响。I. 传入弧的抑制

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