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大肠杆菌脂多糖（LPS）的体内生物学效应。II. 小鼠胸腺中对PHA和伴刀豆球蛋白A有反应的细胞的选择

Biological effects of Escherichia coli lipopolysaccharide (LPS) in vivo. II. Selection in the mouse thymus of PHA- and con A-responsive cells.

作者信息

Adorini L, Ruco L, Uccini S, De Franceschi G S, Baroni C D, Doria G

出版信息

Immunology. 1976 Aug;31(2):225-32.

PMID:783042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445131/
Abstract

The effect of LPS injection on mouse thymocytes was examined by in vitro stimulation with PHA and Con A. Thymocytes from LPS treated mice were found more responsive than normal thymocytes to PHA and Con A. The increase of responsiveness was different for PHA and Con A, and dependent on the dose of LPS injected. This dose dependency suggests that LPS in vivo modifies the thymocyte population by progressively eliminating T1 cells and selecting T2 cells. These effects seem to be mediated by corticosteroids because they were prevented by adrenalectomy, a finding in agreement with the notion that the injection of cortisone induces similar cell changes in the thymus.

摘要

通过用PHA和Con A进行体外刺激，研究了注射LPS对小鼠胸腺细胞的影响。发现来自LPS处理小鼠的胸腺细胞比正常胸腺细胞对PHA和Con A更敏感。PHA和Con A的反应性增加有所不同，且依赖于注射的LPS剂量。这种剂量依赖性表明，体内的LPS通过逐步消除T1细胞和选择T2细胞来改变胸腺细胞群体。这些作用似乎是由皮质类固醇介导的，因为肾上腺切除术可阻止这些作用，这一发现与注射可的松在胸腺中诱导类似细胞变化的观点一致。

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本文引用的文献

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