Fazio F, Fieschi C, Collice M, Nardini M, Banfi F, Possa M, Spinelli F
J Nucl Med. 1980 Dec;21(12):1139-45.
Continuous carotid infusion of short-lived krypton-81m (t1/2 13 sec) yields an assessment of regional cerebral perfusion. This assessment can be obtained in three dimensions if activity is recorded with a rotating gamma camera and a computer to reconstruct krypton-81m distribution in tomographic sections. These showed several advantages over conventional views: (a) visualization of blood-flow distribution within brain structures (gray and white matter, basal ganglia); (b) more accurate location and evaluation of areas of relatively reduced or increased perfusion; (c) better definition of patterns of collateral circulation; (d) greater sensitivity and specificity in detecting and defining blood-flow changes during physiological activation studies. A limitation of the krypton-81m technique is its invasiveness. However, this study shows that the combination of new advances in radiochemistry with single-photon emission computed tomography may result in accessible methods for assessing, noninvasively and in three dimensions, the behavior of cerebral function in man.
持续经颈动脉注入半衰期较短的氪-81m（t1/2 13秒）可对局部脑灌注进行评估。如果用旋转γ相机和计算机记录放射性，以重建氪-81m在断层切片中的分布，就能在三维空间获得这种评估。这些结果显示出比传统视图具有几个优势：（a）可视化脑结构（灰质和白质、基底神经节）内的血流分布；（b）更准确地定位和评估灌注相对减少或增加的区域；（c）更好地界定侧支循环模式；（d）在生理激活研究中检测和界定血流变化时具有更高的敏感性和特异性。氪-81m技术的一个局限性是其具有侵入性。然而，本研究表明，放射化学方面的新进展与单光子发射计算机断层扫描相结合，可能会产生可用于非侵入性三维评估人类脑功能行为的方法。
