Fazio F, Lenzi G L, Gerundini P, Collice M, Gilardi M C, Colombo R, Taddei G, Del Maschio A, Paicentini M, Kung H F
J Comput Assist Tomogr. 1984 Oct;8(5):911-21. doi: 10.1097/00004728-198410000-00021.
The feasibility of assessing regional cerebral perfusion using the new brain imaging agent N,N,N'-trimethyl-N'-(2)-hydroxy-3-methyl-5-(123I) iodobenzyl)-1,3-propanediamine 2 HCl (I-123 HIPDM) and single photon emission computed tomography (SPECT) was evaluated in normal subjects and patients with cerebrovascular disorders. Following intravenous injection, I-123 HIPDM was rapidly extracted from the circulating blood by the brain (6.7%) and other organs. Its intracerebral distribution, as tomographically assessed by SPECT with a rotating gamma camera, reflected the distribution of blood flow within brain structures (gray and white matter, basal ganglia, etc.). Asymptomatic patients with history of transient ischemic attacks or minor stroke and angiographic evidence of internal carotid artery occlusion showed large cortical areas of reduced I-123 HIPDM distribution with normal or slightly positive CT. After extracranial-intracranial bypass surgery, reperfusion could be shown in previously ischemic areas. This study indicates the clinical usefulness of using I-123 HIPDM and gamma camera SPECT for the functional evaluation of brain disorders.
在正常受试者和脑血管疾病患者中评估了使用新型脑显像剂N，N，N'-三甲基-N'-(2)-羟基-3-甲基-5-(123I)碘苄基)-1,3-丙二胺二盐酸盐（I-123 HIPDM）和单光子发射计算机断层扫描（SPECT）来评估局部脑灌注的可行性。静脉注射后，I-123 HIPDM被脑（6.7%）和其他器官迅速从循环血液中摄取。通过带有旋转γ相机的SPECT进行断层扫描评估，其脑内分布反映了脑结构（灰质和白质、基底神经节等）内的血流分布。有短暂性脑缺血发作或轻度卒中病史且有颈内动脉闭塞血管造影证据的无症状患者，其I-123 HIPDM分布减少的皮质区域较大，而CT正常或略呈阳性。在颅外-颅内搭桥手术后，可在先前缺血区域显示再灌注。本研究表明使用I-123 HIPDM和γ相机SPECT对脑部疾病进行功能评估具有临床实用性。
