食物对琥乙红霉素吸收的影响。
Influence of food on absorption of erythromycin ethyl succinate.
作者信息
Thompson P J, Burgess K R, Marlin G E
出版信息
Antimicrob Agents Chemother. 1980 Nov;18(5):829-31. doi: 10.1128/AAC.18.5.829.
Abstract
Erythromycin plasma concentrations were determined in 18 subjects after a single dose (800 mg) of a new formulation of erythromycin ethyl succinate taken immediately before, immediately after, and 1 h after food. Adequate absorption occurred with all treatments, although bioavailability was best when the drug was taken before food. Absorption was delayed by food, with the highest and earliest peak plasma erythromycin levels occurring under fasting conditions.
摘要
对18名受试者单次服用（800毫克）一种新型琥乙红霉素制剂后的血浆红霉素浓度进行了测定，服药时间分别为进食前、进食后即刻和进食后1小时。所有治疗方案均有足够的吸收，尽管在进食前服药时生物利用度最佳。食物会延迟吸收，空腹条件下血浆红霉素水平达到最高且出现最早。
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