琥乙红霉素在儿科患者中的生物利用度。
Bioavailability of erythromycin ethylsuccinate in pediatric patients.
作者信息
Coyne T C, Shum S, Chun A H, Jeansonne L, Shirkey H C
出版信息
J Clin Pharmacol. 1978 Apr;18(4):194-202. doi: 10.1002/j.1552-4604.1978.tb01593.x.
Abstract
A parallel treatment group bioavailability study was undertaken in children 6 to 65 months of age, comparing fasting and nonfasting erythromycin serum levels after a single oral dose of erythromycin ethylsuccinate granules. Results demonstrated significantly higher levels in the nonfasting than in the fasting state, while fasting state levels were comparable to those found in studies of adult subjects receiving recommended doses of the same compound.
摘要
在6至65个月大的儿童中进行了一项平行治疗组生物利用度研究，比较单次口服琥乙红霉素颗粒后空腹和非空腹状态下的红霉素血清水平。结果表明，非空腹状态下的水平显著高于空腹状态，而空腹状态下的水平与接受相同化合物推荐剂量的成年受试者研究中发现的水平相当。
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