[东亚钳蝎毒液的药理学]
[Pharmacology of the venom from the scorpion, Buthus eupeus].
作者信息
Orlov B N, Egorov V V, Gelashvili D B, Omarov Sh M
出版信息
Farmakol Toksikol. 1980 Nov-Dec;43(6):730-3.
Reactions induced by venom from the scorpion Buthus eupeus and by toxin of the venom have been studied on isolated organs and tissues as well as on intact body. It has been shown that substances interfering with the conduction of nerve excitation, with the mediator storage and interaction of the latter with synaptic receptors prevent the reactions induced by the venom and toxin, whereas ganglion-blocking agents do not affect these reactions. The catecholamine content in rat blood plasma has been found to be increased. It is assumed that the venom and toxin that affect the postganglionic nerve terminals release mediator acetylcholine and noradrenaline.
对东亚钳蝎毒液及其毒素所引发的反应，已在离体器官和组织以及完整机体上进行了研究。结果表明，干扰神经兴奋传导、介质储存以及介质与突触受体相互作用的物质，可阻止毒液和毒素所引发的反应，而神经节阻断剂对这些反应并无影响。已发现大鼠血浆中的儿茶酚胺含量有所增加。据推测，作用于节后神经末梢的毒液和毒素会释放介质乙酰胆碱和去甲肾上腺素。
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