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[东亚钳蝎毒液毒素暴露后大脑和心脏组织中3',5'-环磷酸腺苷和3',5'-环磷酸鸟苷水平的变化]

[Changes in the levels of 3',5'-cAMP and 3',5'-cGMP in brain and heart tissues after exposure to toxins of Buthus eupeus scorpion venom].

作者信息

Orlov B N, Gelashvili D B, Egorov V V, Sidnev B N

出版信息

Biull Eksp Biol Med. 1981 Sep;92(9):290-2.

PMID:6271301
Abstract

Toxins isolated from Buthus eupeus scorpion stimulated the generation of cAMP and cGMP in mouse cerebellar and forebrain slices, as well as in isolated guinea-pig heart. Pharmacological analysis of neurotropic and cardiotropic effects of toxins has ascertained the relationship between the increased level of cyclic nucleotides and catecholaminergic and cholinergic effects of toxins.

摘要

从真钳蝎中分离出的毒素可刺激小鼠小脑和前脑切片以及离体豚鼠心脏中cAMP和cGMP的生成。对毒素的神经otropic和心脏otropic作用进行的药理学分析确定了环核苷酸水平升高与毒素的儿茶酚胺能和胆碱能作用之间的关系。

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1
[Changes in the levels of 3',5'-cAMP and 3',5'-cGMP in brain and heart tissues after exposure to toxins of Buthus eupeus scorpion venom].[东亚钳蝎毒液毒素暴露后大脑和心脏组织中3',5'-环磷酸腺苷和3',5'-环磷酸鸟苷水平的变化]
Biull Eksp Biol Med. 1981 Sep;92(9):290-2.
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Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases.环鸟苷酸（cGMP）和环腺苷酸（cAMP）诱导的对照和肥大心肌细胞功能变化通过受cGMP影响的环磷酸腺苷磷酸二酯酶相互作用。
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8
[Amino acid sequence of 2 neurotoxins from the scorpion Buthus eupeus venom].
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