Levitt D, Cooper M D
J Pediatr. 1981 Jan;98(1):52-8. doi: 10.1016/s0022-3476(81)80532-x.
Defects in regulation of the humoral immune system were examined in a family with selective IgA deficiency. Two patients (mother and son) were clinically well and had selective abnormalities of B lymphocytes that can differentiate into IgA plasma cells plus specific T cell suppression of IgA production. One patient (daughter) had several clinical problems and received nine monthly transfusions of normal plasma. Prior to therapy, this patient had abnormal immunoregulation of both B and T lymphocyte population that cooperated in the formation of all cases of immunoglobulin-producing cells. After treatment, her clinical problems were resolved and her cellular abnormalities appeared identical in those in her mother and brother.
在一个患有选择性IgA缺乏症的家族中，对体液免疫系统调节缺陷进行了研究。两名患者（母亲和儿子）临床状况良好，存在B淋巴细胞的选择性异常，这些B淋巴细胞可分化为IgA浆细胞，同时存在特异性T细胞对IgA产生的抑制作用。一名患者（女儿）有多种临床问题，接受了9次每月一次的正常血浆输血。在治疗前，该患者B淋巴细胞和T淋巴细胞群体的免疫调节均异常，这些细胞在所有免疫球蛋白产生细胞的形成过程中相互协作。治疗后，她的临床问题得到解决，其细胞异常情况与她的母亲和兄弟相同。
