Tholen W, Paquet K J, Rohner H G, Albrecht M
Leber Magen Darm. 1980 Aug;10(4):193-7.
A female patient with congenital ichthyosis took vitamin A in an uncontrolled manner throughout 3 years totalling 60 Mill. IU. This lead to cirrhosis of the liver confirmed histologically after biopsy; vitamin A could be demonstrated in tissue of liver and spleen by fluorescence microscopy. Bleeding from esophageal varices could not be stopped by conventional means, but only by sclerosing the esophageal mucosa in the areas affected. A relapse of bleeding from varices of the fornix was stopped by disconnection according to Hassab-Paquet. The patient died from hepatic failure in advanced hepatic cirrhosis. A long time treatment with high doses of vitamin A seems to be a doubtful therapeutic procedure, especially in view of the fact, that side effects of this therapy cannot be monitored by laboratory measurements; when a disturbed liver function becomes evident, irreversible damage, e.g. cirrhosis or fibrosis and portal hypertension, is already present.
一名患有先天性鱼鳞病的女性患者在3年时间里无节制地服用维生素A，总量达6亿国际单位。这导致肝脏活检组织学确诊为肝硬化；通过荧光显微镜检查可在肝脏和脾脏组织中发现维生素A。常规方法无法止住食管静脉曲张出血，只能通过对受影响区域的食管黏膜进行硬化治疗来止血。穹窿部静脉曲张出血复发，按照哈萨布 - 帕凯法进行断流术止血。患者死于晚期肝硬化的肝衰竭。长期大剂量使用维生素A似乎是一种可疑的治疗方法，特别是鉴于这种疗法的副作用无法通过实验室检测进行监测这一事实；当肝功能紊乱明显时，不可逆的损害，如肝硬化、纤维化和门静脉高压已经存在。
