Fleischmann R, Schlote W, Schomerus H, Wolburg H, Castrillon-Oberndorfer W L, Hoensch H
Dtsch Med Wochenschr. 1977 Nov 11;102(45):1637-40. doi: 10.1055/s-0028-1105550.
Clinical and histological signs of small nodular liver cirrhosis with portal hypertension were present in a 36-year-old man, three-and-a-half years after a seven-week course of treatment of psoriasis vulgaris with high doses of vitamin a (70 X 10(6) IU orally). Although there is no increase in serum level of vitamin A now, increased deposits of vitamin A in the perisinusoidal lipid storage cells (Ito cells) are still demonstrated by fluorescencespectrophotometry and under the electron microscope. Fundectomy with resection of the terminal oesophagus was necessary because of bleeding from oesophageal varices.
一名36岁男性在接受了为期7周的大剂量维生素A（口服70×10⁶国际单位）治疗寻常型银屑病三年半后，出现了伴有门静脉高压的小结节性肝硬化的临床和组织学体征。尽管目前血清维生素A水平没有升高，但通过荧光分光光度法和电子显微镜仍可显示维生素A在肝血窦周围脂质储存细胞（伊托细胞）中的沉积增加。由于食管静脉曲张出血，需要进行贲门切除术并切除食管末端。
