Braveny I, Machka K, Bartmann K, Fabricius K, Daschner F, Petersen K F, Grimm H, Ullmann U, Freiesleben H
Dtsch Med Wochenschr. 1980 Sep 26;105(39):1341-4. doi: 10.1055/s-2008-1070868.
In a multi-center study 523 strains of H. influenzae and H. parainfluenzae isolated from patients in eight towns of the Federal Republic of Germany were tested for their sensitivity to 15 different chemotherapeutic agents. 1.7% of the strains were resistant to ampicillin, 1,5% to chloramphenicol and 2.5% to tetracycline. All ampicillin-resistant strains produced beta-lactamase. For the first time, multiple resistant strains were isolated: two against ampicillin, chloramphenicol and tetracycline; one in addition also against co-trimoxazole. It is likely that there will be a spread of such resistant strains.
在一项多中心研究中,对从德意志联邦共和国八个城镇的患者身上分离出的523株流感嗜血杆菌和副流感嗜血杆菌进行了测试,以检测它们对15种不同化疗药物的敏感性。1.7%的菌株对氨苄西林耐药,1.5%对氯霉素耐药,2.5%对四环素耐药。所有对氨苄西林耐药的菌株都产生β-内酰胺酶。首次分离出多重耐药菌株:两株对氨苄西林、氯霉素和四环素耐药;一株还对复方新诺明耐药。这种耐药菌株很可能会传播开来。