Dabernat H J, Delmas C, Bauriaud R, Lareng M B
Ann Microbiol (Paris). 1979 May-Jun;130 A(4):469-79.
Bactericidal activity of three antibiotics, ampicillin, chloramphenicol and gentamicin, alone or in combinations, was determined against susceptible and resistant strains of Haemophilus influenzae. The various antibiotic combinations were studied for the determination of a synergistic or antagonistic effect. The study was done by the checkerboard method. A percentage of survivors inferior or equal to 0.01% of the inoculum represents the bactericidal activity. Ampicillin and chloramphenicol are bactericidal antibiotics against H. influenzae at concentrations of 1 microgram/ml and 4 microgram/ml, respectively. The combination of ampicillin and gentamicin exhibited a synergistic effect against strains sensitive and resistant to ampicillin. The combination of chloramphenicol and gentamicin was synergistic against all strains. Ampicillin and chloramphenicol, when combined, were antagonistic against two strains using a bacteriostatic concentration of chloramphenicol; and against the remaining strains the effects of the combination were indifferent.
测定了氨苄西林、氯霉素和庆大霉素这三种抗生素单独使用及联合使用时对流感嗜血杆菌敏感菌株和耐药菌株的杀菌活性。研究了各种抗生素组合以确定其协同或拮抗作用。该研究采用棋盘法进行。存活率低于或等于接种物的0.01%表示具有杀菌活性。氨苄西林和氯霉素分别在浓度为1微克/毫升和4微克/毫升时对流感嗜血杆菌具有杀菌作用。氨苄西林和庆大霉素的组合对氨苄西林敏感和耐药的菌株均表现出协同作用。氯霉素和庆大霉素的组合对所有菌株均具有协同作用。当联合使用时，氨苄西林和氯霉素在使用抑菌浓度的氯霉素时对两株菌具有拮抗作用；而对其余菌株，该组合的效果不明显。
