小鼠淋巴细胞上的环孢菌素受体。
Cyclosporin receptor on mouse lymphocytes.
作者信息
Ryffel B, Donatsch P, Götz U, Tschopp M
出版信息
Immunology. 1980 Dec;41(4):913-9.
Abstract
Specific binding of [3H]-cyclosporin C (3H-CS-C), an immunosuppressive oligopeptide, was characterized on different mouse lymphocytes. The binding was saturable, time-dependent and reversible; and KD of 1.5 x 10(-7) M and maximum binding capacity Bmax of 35 pmol/4 x 10(6) cells was found for thymocytes. A computerized analysis of the data confirmed a single population of high affinity binding sites. Lymphocytes of different organs differed in their Bmax: thymus greater than spleen greater than mesenteric lymph node (pure T cells) greater than mesenteric lymph node (pure B cells). Erythrocytes did not show a specific binding.
摘要
免疫抑制性寡肽[3H]-环孢菌素C（3H-CS-C）在不同小鼠淋巴细胞上的特异性结合得到了表征。该结合具有饱和性、时间依赖性和可逆性；胸腺细胞的解离常数KD为1.5×10⁻⁷ M，最大结合容量Bmax为35 pmol/4×10⁶个细胞。对数据的计算机分析证实存在单一群体的高亲和力结合位点。不同器官的淋巴细胞在其Bmax上存在差异：胸腺＞脾脏＞肠系膜淋巴结（纯T细胞）＞肠系膜淋巴结（纯B细胞）。红细胞未显示出特异性结合。
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