对绵羊红细胞具有特异性的腹膜渗出液T淋巴细胞。IV. 特异性腹膜渗出液淋巴细胞上的Fc受体及其在迟发型超敏反应中的作用。
Peritoneal exudate T lymphocytes with specificity to sheep red blood cells. IV. Fc receptors on specific peritoneal exudate lymphocytes and their role in delayed-type hypersensitivity reactions.
作者信息
Kaufmann S H, Hahn H
出版信息
Immunology. 1981 Feb;42(2):185-90.
In mice, delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC) is mediated by T cells. Peritoneal exudate T cells (PETLs) from mice optimally sensitized for DTH to SRBC form rosettes when interacted with sensitized sheep red blood cells (EA). The binding of EA to PETLs is mediated by a receptor specific for the Fc portion of the antibody (FcR). Biological activity (mediation of DTH) depends on the unreacted state of PETLs and is lost when the latter are either rosetted with EA or reacted with aggregated IgG. Transfer of EA or aggregated IgG-treated PETLs from mice with DTH to SRBC does not lead to adoptive sensitization of recipients. It is suggested that FcR found on the membrane of T cells mediating DTH play a role in the regulation of the cellular immune response to SRBC.
在小鼠中，对绵羊红细胞（SRBC）的迟发型超敏反应（DTH）由T细胞介导。来自对SRBC的DTH反应最佳致敏的小鼠的腹腔渗出液T细胞（PETL）在与致敏绵羊红细胞（EA）相互作用时会形成花环。EA与PETL的结合由针对抗体Fc部分的特异性受体（FcR）介导。生物活性（DTH的介导）取决于PETL的未反应状态，当后者与EA形成花环或与聚集的IgG反应时，生物活性丧失。将来自对SRBC有DTH反应的小鼠的EA或经聚集IgG处理的PETL转移给受体不会导致受体的过继致敏。有人提出，介导DTH的T细胞膜上发现的FcR在对SRBC的细胞免疫反应调节中起作用。
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