• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

无胸腺影响的自身主要组织相容性复合体限制的细胞毒性T细胞应答。

Self-MHC-restricted cytotoxic T-cell response without thymic influence.

作者信息

Ando I

出版信息

Nature. 1981 Feb 5;289(5797):494-5. doi: 10.1038/289494a0.

DOI:10.1038/289494a0
PMID:6970338
Abstract

The thymus has a central role in directing the maturation and differentiation of T cells. These processes involve movement of cells. These processes involve movement of cells of haematopoietic origin through the thymus and are supposed to require intimate physical contact between T lymphocytes and cells of the thymic epithelium. Cytotoxic T cells (CTLs) induced by virus-infected or hapten-modified autologous cells exhibit dual specificity: for the products of the self major histocompatibility complex (MHC, H--2 in the mouse) and for the foreign antigen. It has been proposed that 'self' specificity of MHC-restricted CTLs is determined by the MHC-encoded antigens expressed on the surface of thymic epithelial cells. We show here that the differentiation of MHC-restricted CTLs can take place without thymic influence. In these experiments, self-MHC-restricted CTLs differentiate form spleen cells of nu/nu mice which lack thymuses after stimulation with 2,4,6-trinitrophenyl (TNP)-coupled autologous cells in the presence of T-cell growth factor.

摘要

胸腺在指导T细胞的成熟和分化过程中起着核心作用。这些过程涉及细胞的移动。这些过程包括造血起源的细胞通过胸腺的移动，并且据推测需要T淋巴细胞与胸腺上皮细胞之间密切的物理接触。由病毒感染或半抗原修饰的自体细胞诱导的细胞毒性T细胞（CTL）表现出双重特异性：针对自身主要组织相容性复合体（MHC，小鼠中的H-2）的产物以及针对外来抗原。有人提出，MHC限制的CTL的“自身”特异性是由胸腺上皮细胞表面表达的MHC编码抗原决定的。我们在此表明，MHC限制的CTL的分化可以在没有胸腺影响的情况下发生。在这些实验中，在T细胞生长因子存在的情况下，用2,4,6-三硝基苯基（TNP）偶联的自体细胞刺激后，缺乏胸腺的裸鼠（nu/nu）的脾细胞可分化形成自身MHC限制的CTL。

相似文献

1
Self-MHC-restricted cytotoxic T-cell response without thymic influence.无胸腺影响的自身主要组织相容性复合体限制的细胞毒性T细胞应答。
Nature. 1981 Feb 5;289(5797):494-5. doi: 10.1038/289494a0.
2
The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.胸腺的H-2表型决定了胸腺移植裸鼠中胸腺而非脾脏细胞毒性T淋巴细胞前体所表达的自身特异性。
J Immunol. 1981 Nov;127(5):2168-76.
3
H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.作为有意致敏结果的H-2限制。正常小鼠胸腺细胞内同种抗原限制的、三硝基苯基特异性细胞毒性T淋巴细胞前体的频率分析。
J Exp Med. 1981 Jun 1;153(6):1629-39. doi: 10.1084/jem.153.6.1629.
4
Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。
J Exp Med. 1981 Jun 1;153(6):1517-32. doi: 10.1084/jem.153.6.1517.
5
Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.胸腺决定主要组织相容性复合体（MHC）的特异性以及II类MHC限制性T细胞的免疫反应基因表型，但不决定I类MHC限制性T细胞的免疫反应基因表型。
J Exp Med. 1984 Dec 1;160(6):1752-66. doi: 10.1084/jem.160.6.1752.
6
Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.裸鼠T细胞表达的自身识别特异性。在确实表现出自身K/D限制性T细胞应答的裸鼠中未检测到Ia限制性T细胞。
J Exp Med. 1984 Sep 1;160(3):839-57. doi: 10.1084/jem.160.3.839.
7
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.同种异体辐射骨髓嵌合体中的细胞毒性T淋巴细胞反应。嵌合宿主严格决定Ia限制性T细胞的自身 repertoire，但不决定H-2K/D限制性T细胞的自身 repertoire。
J Exp Med. 1982 Dec 1;156(6):1650-64. doi: 10.1084/jem.156.6.1650.
8
Transplantation of cultured thymic fragments. VI. H-2 recombinant donors.培养胸腺片段的移植。VI. H-2重组供体。
J Immunol. 1985 Aug;135(2):947-53.
9
MHC restriction of murine T lymphocyte reactivity analysed by growth of bone marrow cells in vitro on thymus epithelial monolayers.通过体外在胸腺上皮单层上培养骨髓细胞分析小鼠T淋巴细胞反应性的MHC限制。
Immunology. 1979 Dec;38(4):835-46.
10
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.

引用本文的文献

1
Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.胸腺细胞毒性T淋巴细胞对胸腺前遇到的同种异体H-2决定簇的耐受性：进入胸腺之前抗H-2受体表达的证据。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):2003-7. doi: 10.1073/pnas.79.6.2003.
2
During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors.在淋巴再生过程中，主要组织相容性复合体限制的细胞毒性T细胞的前体细胞比同种异体反应性前体细胞更早出现。
J Exp Med. 1982 Jan 1;155(1):327-32. doi: 10.1084/jem.155.1.327.
3
Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction.
H-2抗原表达对杀伤性T细胞特异性、分化及诱导的影响。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6401-5. doi: 10.1073/pnas.78.10.6401.
4
Ontogeny of antigen-presenting activity of haptenized cells in mice: early development of syngeneic T cell-stimulatory cells in thymus.小鼠中半抗原化细胞抗原呈递活性的个体发生：胸腺中同基因T细胞刺激细胞的早期发育。
Immunology. 1984 Jan;51(1):161-8.
5
Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self-H-2 specificity and bearing T cell markers.在无胸腺裸鼠骨髓中从不寻常的自发细胞溶解细胞的前体细胞进行分化，这些细胞表现出抗自身H-2特异性并带有T细胞标记。
J Exp Med. 1983 Nov 1;158(5):1672-92. doi: 10.1084/jem.158.5.1672.
6
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.同种异体辐射骨髓嵌合体中的细胞毒性T淋巴细胞反应。嵌合宿主严格决定Ia限制性T细胞的自身 repertoire，但不决定H-2K/D限制性T细胞的自身 repertoire。
J Exp Med. 1982 Dec 1;156(6):1650-64. doi: 10.1084/jem.156.6.1650.
7
Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.裸鼠T细胞表达的自身识别特异性。在确实表现出自身K/D限制性T细胞应答的裸鼠中未检测到Ia限制性T细胞。
J Exp Med. 1984 Sep 1;160(3):839-57. doi: 10.1084/jem.160.3.839.
8
A reexamination of the role of LYT-2-positive T cells in murine skin graft rejection.对LYT-2阳性T细胞在小鼠皮肤移植排斥反应中作用的重新审视。
J Exp Med. 1984 Jan 1;159(1):57-67. doi: 10.1084/jem.159.1.57.
9
Major histocompatibility restriction of antigen recognition by T cells in a recipient of haplotype mismatched human bone marrow transplantation.单倍型不匹配的人类骨髓移植受者中T细胞对抗原识别的主要组织相容性限制
J Clin Invest. 1983 Sep;72(3):1124-9. doi: 10.1172/JCI111037.
10
Tolerance of thymocytes to allogeneic I region determinants encountered prethymically. Evidence for expression of anti-Ia receptors by T cell precursors before their entry into the thymus.胸腺细胞对胸腺前遇到的同种异体I区决定簇的耐受性。T细胞前体在进入胸腺之前表达抗Ia受体的证据。
J Exp Med. 1982 Jun 1;155(6):1638-52. doi: 10.1084/jem.155.6.1638.