作为有意致敏结果的H-2限制。正常小鼠胸腺细胞内同种抗原限制的、三硝基苯基特异性细胞毒性T淋巴细胞前体的频率分析。
H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.
作者信息
Stockinger H, Bartlett R, Pfizenmaier K, Röllinghoff M, Wagner H
出版信息
J Exp Med. 1981 Jun 1;153(6):1629-39. doi: 10.1084/jem.153.6.1629.
Abstract
An in vitro acute-depletion protocol was used to detect trinitrophenyl (TNP)-specific, allo-major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTL) within thymocytes of inbred mice. After removal of alloreactivity, the negatively selected cells could be sensitized to become TNP-specific, allo-MHC-restricted cytotoxic T cells. A precursors frequency analysis revealed a three- to ninefold lower frequency of allo-MHC-restricted CTL precursors (CTL-P) as compared to self-MHC-restricted CTL-P. The specificity analysis of clonally distributed allo-MHC-restricted CTL-P excluded cross-reactivity as an explanation of allo-MHC restriction. These results provide direct evidence that thymic T cells are composed of a mixture of self-MHC- and allo-MHC-restricted immunocompetent T cells and that antigen-driven selection of precommitted T cells dictates the H-2-restriction phenotype, i.e., H-2 restriction is a consequence of priming.
摘要
采用体外急性耗竭方案，检测近交系小鼠胸腺细胞内三硝基苯基（TNP）特异性、同种异体主要组织相容性复合体（MHC）限制性细胞毒性T淋巴细胞（CTL）。去除同种异体反应性后，阴性选择的细胞可被致敏，成为TNP特异性、同种异体MHC限制性细胞毒性T细胞。前体细胞频率分析显示，与自身MHC限制性CTL前体细胞（CTL-P）相比，同种异体MHC限制性CTL-P的频率低三至九倍。对克隆分布的同种异体MHC限制性CTL-P的特异性分析排除了交叉反应作为同种异体MHC限制的一种解释。这些结果提供了直接证据，表明胸腺T细胞由自身MHC和同种异体MHC限制性免疫活性T细胞混合组成，并且抗原驱动的预先确定的T细胞选择决定了H-2限制表型，即H-2限制是启动的结果。
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Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。
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T cell-mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells.携带与淋巴细胞干细胞移植完全异基因胸腺移植的嵌合小鼠的T细胞介导的细胞毒性免疫反应性。
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T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted cytotoxic T lymphocyte responses across cell-impermeable membranes.体外细胞毒性T淋巴细胞反应过程中的T-T细胞相互作用。III. 抗原特异性T辅助细胞释放非特异性介质，能够帮助诱导跨细胞不可渗透膜的H-2限制性细胞毒性T淋巴细胞反应。
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In vivo sensitization of T cells to hapten-conjugated syngeneic structures of major histocompatibility complex. I. Effect of in vitro culture upon generation of cytotoxic T lymphocytes.体内T细胞对半抗原结合的主要组织相容性复合体同基因结构的致敏作用。I. 体外培养对细胞毒性T淋巴细胞生成的影响。
Eur J Immunol. 1976 Nov;6(11):799-805. doi: 10.1002/eji.1830061109.
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