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在淋巴再生过程中，主要组织相容性复合体限制的细胞毒性T细胞的前体细胞比同种异体反应性前体细胞更早出现。

During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors.

作者信息

Hurme M, Sihvola M, Bång B

出版信息

J Exp Med. 1982 Jan 1;155(1):327-32. doi: 10.1084/jem.155.1.327.

DOI:10.1084/jem.155.1.327
PMID:6976415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186559/
Abstract

Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4,6 trinitrophenyl-specific CTL responses could be obtained at this stage. A low alloresponse was first seen 2 wk after Cy injection.

摘要

给小鼠注射亚致死剂量的环磷酰胺（Cy）（300毫克/千克），然后观察再生脾形成针对2,4,6 - 三硝基苯偶联的同基因细胞或异基因细胞的细胞毒性T淋巴细胞（CTL）的能力变化。结果发现，注射Cy后8天，脾中含有能够产生CTL的细胞，但在此阶段只能获得针对2,4,6 - 三硝基苯的特异性CTL反应。注射Cy后2周首次出现低水平的同种异体反应。

相似文献

1
During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors.在淋巴再生过程中，主要组织相容性复合体限制的细胞毒性T细胞的前体细胞比同种异体反应性前体细胞更早出现。
J Exp Med. 1982 Jan 1;155(1):327-32. doi: 10.1084/jem.155.1.327.
2
The origin of cytotoxic T lymphocyte precursors (CTL-P): MHC-restricted and alloreactive CTL-P in the spleen during regeneration after a sublethal dose of cyclophosphamide (Cy).细胞毒性T淋巴细胞前体（CTL-P）的起源：在亚致死剂量环磷酰胺（Cy）后再生过程中脾脏中的MHC限制性和同种反应性CTL-P。
J Immunol. 1983 Mar;130(3):1077-83.
3
The secondary cytotoxic response to trinitrophenyl (TNP) modified syngeneic lymphocytes: effectors generated in vitro differ from those generated in vivo.
Scand J Immunol. 1978;8(2):91-7. doi: 10.1111/j.1365-3083.1978.tb00500.x.
4
Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。
J Exp Med. 1981 Jun 1;153(6):1517-32. doi: 10.1084/jem.153.6.1517.
5
Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes.主要组织相容性复合体限制性T淋巴细胞上的抗原受体。I. 抗三硝基苯基激活的T细胞母细胞的同基因抗血清的制备与特性鉴定，以及其对细胞毒性T淋巴细胞独特型特异性的证明。
J Exp Med. 1980 May 1;151(5):1166-87. doi: 10.1084/jem.151.5.1166.
6
The induction of cytolytic T lymphocytes with syngeneic trinitrophenyl-coupled membranes.用同基因三硝基苯基偶联膜诱导细胞毒性T淋巴细胞。
J Immunol. 1979 Jul;123(1):501-2.
7
H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.作为有意致敏结果的H-2限制。正常小鼠胸腺细胞内同种抗原限制的、三硝基苯基特异性细胞毒性T淋巴细胞前体的频率分析。
J Exp Med. 1981 Jun 1;153(6):1629-39. doi: 10.1084/jem.153.6.1629.
8
Ontogeny of anti-self-trinitrophenyl cytotoxic T-cell responses.抗自身三硝基苯基细胞毒性T细胞反应的个体发生
Thymus. 1981 Aug;3(2):77-85.
9
Frequencies of alloreactive and self-restricted cytotoxic T cell precursors during lymphatic regeneration.
J Immunol. 1983 Aug;131(2):548-50.
10
The cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. I. Evidence for antigen-specific helper T cells.细胞溶解性T淋巴细胞对三硝基苯修饰的同基因细胞的反应。I. 抗原特异性辅助性T细胞的证据。
J Immunol. 1979 Sep;123(3):1205-9.

引用本文的文献

1
Defective repertoire of proliferative T cells during lymphatic regeneration.淋巴管再生过程中增殖性T细胞库存在缺陷。
Immunology. 1984 Feb;51(2):313-8.
2
Lethal vaccinia infection in cyclophosphamide-suppressed mice is associated with decreased expression of Thy-1, Lyt-2 and L3T4 and diminished IL-2 production in surviving T cells.环磷酰胺抑制的小鼠发生致死性痘苗病毒感染与Thy-1、Lyt-2和L3T4表达降低以及存活T细胞中IL-2产生减少有关。
Immunology. 1988 Mar;63(3):423-9.

本文引用的文献

1
Theoretical considerations and probability models for the somatic development of the T-cell repertoire.
Cell Immunol. 1981 Jan 1;57(1):251-64. doi: 10.1016/0008-8749(81)90137-4.
2
Self-MHC-restricted cytotoxic T-cell response without thymic influence.无胸腺影响的自身主要组织相容性复合体限制的细胞毒性T细胞应答。
Nature. 1981 Feb 5;289(5797):494-5. doi: 10.1038/289494a0.
3
Quantitation and cloning of cytolytic T lymphocytes and their precursors.细胞溶解性T淋巴细胞及其前体的定量与克隆
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Specificity of cytotoxic T cells from athymic mice.无胸腺小鼠细胞毒性T细胞的特异性
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
6
Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
Eur J Immunol. 1974 Aug;4(8):527-33. doi: 10.1002/eji.1830040802.
7
Induction of suppressor cells in mice by cyclophosphamide.
Ann Immunol (Paris). 1978 Apr-Jun;129 C(4):475-87.
8
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.
9
Splenic modifications induced by cyclophosphamide in C3H/He, nude, and "B" mice.
J Immunol. 1977 May;118(5):1595-9.
10
Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.同种异体反应性的生物学意义：被仙台病毒包被的同基因细胞刺激的T细胞特异性裂解异基因靶细胞。
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9. doi: 10.1073/pnas.75.10.5145.