在淋巴再生过程中，主要组织相容性复合体限制的细胞毒性T细胞的前体细胞比同种异体反应性前体细胞更早出现。
During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors.
作者信息
Hurme M, Sihvola M, Bång B
出版信息
J Exp Med. 1982 Jan 1;155(1):327-32. doi: 10.1084/jem.155.1.327.
Abstract
Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4,6 trinitrophenyl-specific CTL responses could be obtained at this stage. A low alloresponse was first seen 2 wk after Cy injection.
摘要
给小鼠注射亚致死剂量的环磷酰胺（Cy）（300毫克/千克），然后观察再生脾形成针对2,4,6 - 三硝基苯偶联的同基因细胞或异基因细胞的细胞毒性T淋巴细胞（CTL）的能力变化。结果发现，注射Cy后8天，脾中含有能够产生CTL的细胞，但在此阶段只能获得针对2,4,6 - 三硝基苯的特异性CTL反应。注射Cy后2周首次出现低水平的同种异体反应。
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During lymphatic regeneration, precursors for major histocompatibility complex-restricted cytotoxic T cells appear before alloreactive precursors.在淋巴再生过程中，主要组织相容性复合体限制的细胞毒性T细胞的前体细胞比同种异体反应性前体细胞更早出现。
J Exp Med. 1982 Jan 1;155(1):327-32. doi: 10.1084/jem.155.1.327.
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本文引用的文献
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Theoretical considerations and probability models for the somatic development of the T-cell repertoire.
Cell Immunol. 1981 Jan 1;57(1):251-64. doi: 10.1016/0008-8749(81)90137-4.
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Quantitation and cloning of cytolytic T lymphocytes and their precursors.细胞溶解性T淋巴细胞及其前体的定量与克隆
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Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
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On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
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Proc Natl Acad Sci U S A. 1978 Oct;75(10):5145-9. doi: 10.1073/pnas.75.10.5145.
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