Cooper I S, Upton A R, Rappaport Z H, Amin I
Acta Neurochir Suppl (Wien). 1980;30:339-44. doi: 10.1007/978-3-7091-8592-6_41.
The value of clinical assessment of patients undergoing chronic cerebellar stimulation (CCS) is limited by lack of objective measures but neurophysiological tests can be used to "biocalibrate" the stimulator and may be used to predict effects of CCS. Eighty-seven patients undergoing CCS have been assessed clinically and neurophysiologically over the last 4 years. Somatosensory evoked responses were significantly ( p less than 0.05) reduced in amplitude in 35 patients, cortical somatosensory evoked responses in 44 patients and one or both responses were reduced in 55 patients. There were no clinical or physiological changes in 16 patients. Evoked responses showed significant changes in only 3 patients who did not show clinical improvement. The mean voltage settings were 5.2 volts and most patients were stimulated at 200 herz. These results indicate that significant changes in those somatosensory evoked potentials are a good indication of clinical benefits from CCS but clinical improvement may occur in the absence of any acute effect on evoked responses.
慢性小脑刺激（CCS）患者的临床评估价值因缺乏客观指标而受限，但神经生理学测试可用于对刺激器进行“生物校准”，并可用于预测CCS的效果。在过去4年中，对87例接受CCS治疗的患者进行了临床和神经生理学评估。35例患者的体感诱发电位振幅显著降低（p<0.05），44例患者的皮层体感诱发电位降低，55例患者的一种或两种反应均降低。16例患者无临床或生理变化。仅3例未显示临床改善的患者诱发电位有显著变化。平均电压设置为5.2伏，大多数患者以200赫兹进行刺激。这些结果表明，那些体感诱发电位的显著变化是CCS临床获益的良好指标，但在诱发电位无任何急性效应的情况下也可能出现临床改善。
