Hershler C, Upton A R, Debruin H, Burcea I, King R N, Zoghaib C
G.F. Strong Rehabilitation Centre, Vancouver, B.C.
Pacing Clin Electrophysiol. 1989 May;12(5):861-9. doi: 10.1111/j.1540-8159.1989.tb01911.x.
A single (N = 1) spastic cerebral palsy adult who had experienced Chronic Cerebellar Stimulation (CCS) for 9 years without any change in the stimulator settings was assessed at six different stimulator settings. These voltage settings varied from 0 volts to 40 volts and frequencies of stimulation from 0 to 200 Hz. Stimulation was with bipolar rectangular pulses with less than 0.2 C/mm2 charge per phase. Responses measured at each setting were quantitative gait, speech, and somatosensory evoked potential measurements. Additional clinical assessments were done by a neurologist and speech therapist. Alteration in stimulator settings occurred 1 week apart to allow for stabilization and all assessments were completed in the same sequence each day. None of the individual stimulator settings were known to any of the assessors or to the patient. The results showed consistently that the patient's gait and speech were poorest when the stimulator was switched off completely. Switching on the stimulator caused improved function according to all assessments. There was consistent improvement in gait and speech when the rate of the cerebellar stimuli was high (for voltages between 0 and 40 V). Changing the voltage (within the range 0 to 40 V), while keeping the frequency of stimulation constant, did not appear to have as much effect. This preliminary evaluation suggests that the technique of CCS is safe and can improve function in a measurable manner.
一名患有痉挛性脑瘫的成年人（N = 1），已接受慢性小脑刺激（CCS）9年，刺激器设置未作任何改变，在六种不同的刺激器设置下接受了评估。这些电压设置从0伏到40伏不等，刺激频率从0到200赫兹。刺激采用双极矩形脉冲，每相电荷小于0.2库仑/平方毫米。在每种设置下测量的反应包括定量步态、言语和体感诱发电位测量。由神经科医生和言语治疗师进行额外的临床评估。刺激器设置的改变相隔1周进行，以确保稳定，且所有评估每天都按相同顺序完成。评估人员和患者均不知道任何单个刺激器设置。结果始终表明，当刺激器完全关闭时，患者的步态和言语最差。根据所有评估，开启刺激器可改善功能。当小脑刺激频率较高时（电压在0至40伏之间），步态和言语持续改善。在保持刺激频率不变的情况下改变电压（在0至40伏范围内）似乎效果不明显。这项初步评估表明，慢性小脑刺激技术是安全的，并且可以以可测量的方式改善功能。
