小鼠中乙酰化表型的遗传
Inheritance of acetylator phenotype in mice.
作者信息
Tannen R H, Weber W W
出版信息
J Pharmacol Exp Ther. 1980 Jun;213(3):480-4.
The inheritance of two acetylator traits in a new mouse model of the human isoniazid acetylator polymorphism has been characterized. A/J mice have little or no blood p-aminobenzoic acid N-acetyltransferase activity and can excrete a low ratio of acetylsulfamethazine to sulfamethazine in urine. C57BL/6J mice have considerable blood p-aminobenzoic acid N-acetyltransferase activity and can excrete a high ratio of acetylsulfamethazine to sulfamethazine in urine. The expression of the blood p-aminobenzoic acid acetylation trait in F1, F2 and backcross progeny from A/J and C57BL/6J matings is consistent with simple Mendelian inheritance of two codominant alleles. Inheritance of in vivo acetylation rate, as measured by urinary ratio of acetylsulfamethazine to sulfamethazine, is independent of the blood acetylator polymorphism and is probably governed by simple Mendelian inheritance with incomplete dominance of low urinary ratio over high. Incomplete dominance appears to be limited to animals bearing one or two genes for rapid acetylation of p-aminobenzoic acid by blood hemolysates.
在人类异烟肼乙酰化多态性的一种新小鼠模型中，两种乙酰化性状的遗传特征已被描述。A/J小鼠几乎没有或完全没有血液对氨基苯甲酸N - 乙酰转移酶活性，并且在尿液中排泄的乙酰磺胺二甲嘧啶与磺胺二甲嘧啶的比例较低。C57BL/6J小鼠具有相当高的血液对氨基苯甲酸N - 乙酰转移酶活性，并且在尿液中排泄的乙酰磺胺二甲嘧啶与磺胺二甲嘧啶的比例较高。来自A/J和C57BL/6J交配的F1、F2和回交后代中血液对氨基苯甲酸乙酰化性状的表达与两个共显性等位基因的简单孟德尔遗传一致。通过尿液中乙酰磺胺二甲嘧啶与磺胺二甲嘧啶的比例测量的体内乙酰化速率的遗传，独立于血液乙酰化多态性，可能受简单孟德尔遗传控制，低尿液比例对高尿液比例呈不完全显性。不完全显性似乎仅限于携带一个或两个使血液溶血产物对氨基苯甲酸快速乙酰化基因的动物。
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