对5-硝基咪唑耐药的滴虫菌株具有活性的新型化疗硝基杂环化合物。
New chemotherapeutic nitroheterocycles active against 5-nitroimidazole-resistant strains of trichomonads.
作者信息
Meingassner J G, Nesvadba H, Mieth H
出版信息
Arzneimittelforschung. 1981;31(1):6-8.
PMID:6971111
Abstract
The synthesis and the trichomonacidal activity of some 4-substituted 2-imidazolylquinazoline derivatives are described. The new compounds were highly active against metronidazole-sensitive and metronidazole-resistant strains of trichomonads. This was demonstrated in vitro as well as in various trichomoniasis models in mice and rats after oral treatment.
摘要
描述了一些4-取代的2-咪唑基喹唑啉衍生物的合成及其杀滴虫活性。新化合物对甲硝唑敏感和耐药的滴虫菌株具有高活性。口服给药后，在体外以及小鼠和大鼠的各种滴虫病模型中均证实了这一点。
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