用钚 - 239产生的α粒子进行体外照射对人淋巴细胞染色体畸变的诱导作用。
The induction of chromosome aberrations in human lymphocytes by in vitro irradiation with alpha-particles from plutonium-239.
作者信息
Purrott R J, Edwards A A, Lloyd D C, Stather J W
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Sep;38(3):277-84. doi: 10.1080/09553008014551641.
The yields of unstable chromosome aberrations induced in human lymphocytes by alpha-particles from plutonium-239 have been measured. Plutonium citrate solution was mixed with heparinized blood so that doses of 13--160 rad were delivered in 24 hours. Dicentric aberration yields (Y) fitted best to the linear expression Y = 3 . 72 +/- 0 . 23 x 10(-3) rad-1. Inclusion of a 6 . 5 rad point resulting from a 1 . 7 hour irradiation raised the yield coefficient insignificantly to 3 . 75 +/- 0 . 24 x 10(-3). The aberration yields are in good agreement with data from curium-242 alpha-particles obtained in this laboratory but they are much lower than those obtained in two other laboratories. Reasons for this disagreement are examined.
已对钚 - 239产生的α粒子在人淋巴细胞中诱导产生的不稳定染色体畸变率进行了测量。将柠檬酸钚溶液与肝素化血液混合，以便在24小时内给予13 - 160拉德的剂量。双着丝粒畸变率（Y）最符合线性表达式Y = 3.72 ± 0.23×10⁻³拉德⁻¹。由1.7小时照射产生的6.5拉德的数据点纳入后，产率系数小幅提高至3.75 ± 0.24×10⁻³。畸变率与本实验室获得的锔 - 242α粒子的数据吻合良好，但远低于其他两个实验室获得的数据。本文研究了这种差异的原因。
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