Sheremet'eva G F, Kniazev M D, Martynov A A, Seleznev M N
Kardiologiia. 1981 Feb;21(2):69-73.
To evaluate the efficacy of combined cold and pharmacological protection of the myocardium in aortocoronary shunting, study of myocardial ultrastructure with quantitative stereological analysis of the mitochondria was conducted in 56 puncture biopsies; the material was collected in 28 patients with chronic ischemic heart disease before the aorta was clamped and after the clamp was removed. The period of anoxia did not exceed 68 minutes. The absence of irreparable morphological changes in the cardiomyocytes correlated with the character of restoration of cardiac activity and function after the operation, which allowed the conclusion that this is an effective method for protecting the myocardium of patients with chronic ischemic heart disease from anoxia during 68 minutes of cardioplegia.
为评估在主动脉冠状动脉分流术中联合冷灌注与药物保护心肌的疗效，对56份穿刺活检组织进行了线粒体定量立体分析的心肌超微结构研究；材料取自28例慢性缺血性心脏病患者，分别于主动脉阻断前和阻断解除后采集。缺氧时间不超过68分钟。心肌细胞未出现不可修复的形态学改变与术后心脏活动和功能的恢复情况相关，由此得出结论：这是一种在心脏停搏68分钟期间保护慢性缺血性心脏病患者心肌免受缺氧影响的有效方法。
