Rolly G, Versichelen L, Zubair N A
Acta Anaesthesiol Belg. 1980;31(4):241-7.
ICI 35868 was used to induce anesthesia in 39 ASA I patients (9 male and 30 female, aged 17-64 years), scheduled to undergo minor surgical procedures. The first 6 patients were given 1.0 mg/kg, the next 22 1.5 mg/kg and the final 11 2.0 mg/kg ICI 35868 I.V. over 30 seconds, without premedication. Anesthesia was successfully induced in 100% of patients at 2.0 mg/kg, 81% at 1.5 mg/kg and 50% at 1.0 mg/kg. Pain at the injection site occurred in 23% of patients. There were no signs of venous damage postoperatively. A small transient fall in blood pressure and some respiratory depression were seen immediately after induction; transient apnoea occurred in 27% of patients given 1.5 mg/kg and 55% given 2.0 mg/kg. Other side effects were minor and of low incidence. Three minutes after induction of anesthesia, when assessments were complete, 23 patients were given a further dose of a conventional induction agent, as they were beginning to awaken, and anesthesia was maintained in all patients by inhalational techniques. There were no untoward events during maintenance of or on recover from anesthesia.
ICI 35868用于39例美国麻醉医师协会（ASA）I级患者（9例男性，30例女性，年龄17 - 64岁）的麻醉诱导，这些患者计划接受小型外科手术。前6例患者静脉注射1.0 mg/kg ICI 35868，接下来的22例注射1.5 mg/kg，最后11例注射2.0 mg/kg，均在30秒内注射完毕，未进行术前用药。2.0 mg/kg剂量时100%的患者成功诱导麻醉，1.5 mg/kg时为81%，1.0 mg/kg时为50%。23%的患者注射部位出现疼痛。术后未见静脉损伤迹象。诱导后立即出现血压短暂轻微下降和一些呼吸抑制；1.5 mg/kg剂量组27%的患者和2.0 mg/kg剂量组55%的患者出现短暂呼吸暂停。其他副作用轻微且发生率低。麻醉诱导3分钟后，评估完成时，23例患者因开始苏醒而给予另一剂传统诱导剂，所有患者均通过吸入技术维持麻醉。麻醉维持期间及苏醒过程中未发生不良事件。
