Walmsley A J, McLeod B, Ponte J
Eur J Anaesthesiol. 1986 Jan;3(1):19-26.
Thirty unpremedicated patients for day-case surgery were anaesthetized with 2.5 mg kg-1 of a new formulation of I.C.I. 35868 (propofol: Diprivan--I.C.I.) in a lipid emulsion. An initial bolus of fentanyl (1-1.5 micrograms kg-1) was given. Anaesthesia was maintained with intermittent boluses of propofol (1 mg kg-1) with no other agent added. The significant problems were: a high incidence of pain on injection (30%) and apnoea following induction lasting more than 30 s (57%). Cardiovascular depression was significant but not considered excessive. Recovery from the drug was rapid and uneventful, with no reported hangover effect.
30例未用术前药的日间手术患者用2.5毫克/千克的一种新剂型的ICI 35868（丙泊酚：得普利麻——ICI公司生产）脂质乳剂进行麻醉。先给予首剂芬太尼（1 - 1.5微克/千克）。麻醉维持采用丙泊酚间断推注（1毫克/千克），未添加其他药物。主要问题有：注射时疼痛发生率高（30%）以及诱导后呼吸暂停持续超过30秒（57%）。心血管抑制明显但未被认为过度。药物恢复迅速且平稳，未报告有宿醉效应。
