Massonnet-Castel S, Cassuto J P, Rioche M, Mucchielli A, Masseyeff R
Biomedicine. 1981 Feb;34(1):40-6.
The sera of 88 patient suffering from systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) containing antinuclear antibodies (ANA) were studied for: I) the complement fixing capacity of these ANAs: II) their immunoglobulin class. The results showed that: I) ANAs bind complement to a significant extent in 2 patients with SLE out of 3, but not in RA; II) the ANAs which bind complement belong partially or totally to the IgG class, while most of the ANAs from SLE not fixing complement belong to other classes; III) the ANAs from RA were most often from the IgM class and, surprisingly, they did not bind complement; IV) the occurrence of IgM ANA in SLE patients seems to be associated with clinical manifestations of arthritis. This double test (identification of ANA class and complement binding capacity), appears to be a valuable aid in the cases where diagnosis between RA and SLE is questionable.
对88例患有系统性红斑狼疮（SLE）或类风湿性关节炎（RA）且含有抗核抗体（ANA）的患者血清进行了如下研究：I）这些ANA的补体结合能力；II）其免疫球蛋白类别。结果显示：I）在3例SLE患者中，有2例的ANA能在很大程度上结合补体，但RA患者的ANA则不能；II）能结合补体的ANA部分或全部属于IgG类别，而大多数来自SLE但不结合补体的ANA属于其他类别；III）来自RA的ANA最常来自IgM类别，令人惊讶的是，它们不结合补体；IV）SLE患者中IgM ANA的出现似乎与关节炎的临床表现有关。这种双重检测（ANA类别的鉴定和补体结合能力）在RA和SLE诊断存疑的病例中似乎是一种有价值的辅助手段。
