Chellingworth M C, Salmon M, Scott D L, Bacon P A
Rheumatol Int. 1984;4(1):23-5. doi: 10.1007/BF00683880.
An investigation of the incidence of IgG and IgM antinuclear antibodies (ANA) in patients with connective tissue diseases showed that IgM ANA predominated in rheumatoid arthritis, whilst in systemic lupus erythematosus IgG antibodies were more common. Patients with other connective tissue diseases less frequently had antinuclear antibodies and there was little difference in the incidence of IgG and IgM antibodies. Cross reacting rheumatoid factors contributed to the IgM antinuclear activity of rheumatoid sera. IgM ANA was not related to disease activity in patients with rheumatoid arthritis. Immunoglobulin class differences of ANA in rheumatoid arthritis and systemic lupus erythematosus may reflect the differing pathological processes of these two diseases and may be of value in their differential diagnosis.
一项针对结缔组织病患者中IgG和IgM抗核抗体（ANA）发生率的调查显示，IgM ANA在类风湿关节炎中占主导，而在系统性红斑狼疮中IgG抗体更为常见。其他结缔组织病患者抗核抗体的发生率较低，且IgG和IgM抗体的发生率差异不大。交叉反应性类风湿因子导致了类风湿血清的IgM抗核活性。在类风湿关节炎患者中，IgM ANA与疾病活动无关。类风湿关节炎和系统性红斑狼疮中ANA的免疫球蛋白类别差异可能反映了这两种疾病不同的病理过程，对它们的鉴别诊断可能有价值。
