Effect of feeding on plasma uric acid levels in snakes.

The effect of feeding on plasma-uric acid concentrations of the snake was studied. The values were monitored in 2 gopher snakes and 2 black rat snakes which were fed mice. Plasma uric acid values in snakes increased after eating and gradually returned to base line with the digestion of the mice. Uric acid concentrations were greater in snakes eating 2 mice than in those eating only 1 mouse. The base-line plasma uric acid concentration in snakes was approximately 2 to 5 mg/dl. Plasma uric acid concentrations may be useful in making a diagnosis of gout. Presence of gout is usually indicated by increased uric acid concentrations; however, interpretation of these concentrations should be based on information about the feeding schedule.