Pingleton S K, Bone R C, Pingleton W W, Ruth W E
Chest. 1981 Jun;79(6):647-50. doi: 10.1378/chest.79.6.647.
Ninety-eight patients admitted to our respiratory intensive care unit during a one-year period were compared retrospectively with 99 well-matched patients admitted during a second one-year period. The use of prophylactic low-dose heparin in the second year was associated with a significant decrease in pulmonary emboli documented by ventilation-perfusion scan, pulmonary angiography, and autopsy. No specific bleeding complications could be directly attributed to the use of low-dose heparin. The frequency and severity of gastrointestinal hemorrhage as determined by hemoglobin fall and transfusion requirements were not significantly affected by the prophylactic use of low-dose heparin. Low-dose heparin appears to be effective and safe in respiratory intensive care unit patients in the prevention of pulmonary emboli.
对我院呼吸重症监护病房在一年期间收治的98例患者与在第二个一年期间收治的99例匹配良好的患者进行了回顾性比较。第二年使用预防性小剂量肝素与通气灌注扫描、肺血管造影和尸检记录的肺栓塞显著减少有关。没有特定的出血并发症可直接归因于小剂量肝素的使用。通过血红蛋白下降和输血需求确定的胃肠道出血的频率和严重程度未受到预防性使用小剂量肝素的显著影响。小剂量肝素在呼吸重症监护病房患者预防肺栓塞方面似乎有效且安全。
