Cox R, Masson W K, Weichselbaum R R, Nove J, Little J B
Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Apr;39(4):357-65. doi: 10.1080/09553008114550461.
The repair of potentially lethal damage (PLD) after X-rays was studied in plateau phase cultures of nine normal and five ataxia telangiectasia (AT) strains of human fibroblasts. In the normal strains PLD repair was complete after 6 hours of post-irradiation incubation. There were differences in the form of the survival curves of normal strains after maximum PLD repair but the extent of post-irradiation recovery was similar in all strains. In contrast all AT strains were almost completely deficient in PLD repair even when post-irradiation incubation was extended to 18 or 24 hours. The relevance of the PLD repair-deficiency in cultured AT strains to in vivo radiotherapeutic observations in AT patients is briefly discussed.
在9株正常人成纤维细胞和平共处5株共济失调毛细血管扩张症（AT）患者的成纤维细胞的平台期培养物中，研究了X射线照射后潜在致死性损伤（PLD）的修复情况。在正常细胞株中，照射后孵育6小时，PLD修复完成。最大PLD修复后，正常细胞株存活曲线的形式存在差异，但所有细胞株照射后的恢复程度相似。相比之下，所有AT细胞株即使将照射后孵育时间延长至18或24小时，PLD修复也几乎完全缺失。文中简要讨论了培养的AT细胞株中PLD修复缺陷与AT患者体内放射治疗观察结果的相关性。
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