Ito N, Mergenhagen S E, Rosenstreich D L
J Periodontol. 1981 Apr;52(4):190-6. doi: 10.1902/jop.1981.52.4.190.
AN IMMUNOLOGICAL comparison of ODU Plaque-Resistant (RES) and Plaque-Susceptible (SUS) Rats was performed in order to determine if plaque accumulation was secondary to some immunological abnormality, and to ascertain the effects of plaque accumulation on the immune system. Plaque accumulation in SUS rats on powder diets is associated with a significant elevation in immunoglobulin levels over RES rats, especially in serum IgG and IgM. Young (less than 9 weeks) SUS rats possess fewer splenic T lymphocytes than do young RES rats. This decrease is associated with a marked decrease in the response of spleen cells in vitro to T cell mitogens, Con A and PHA. This decrease is unrelated to diet and is completely and spontaneously reversed in the adult (3 month) rats. These studies demonstrate that the accumulation of large amounts of plaque cause an elevation in immunoglobulin levels. However, plaque accumulation in SUS rats does not appear to be secondary to any demonstrable immunologic abnormality.
为了确定菌斑积聚是否继发于某些免疫异常，并确定菌斑积聚对免疫系统的影响，对ODU抗菌斑（RES）大鼠和菌斑易感（SUS）大鼠进行了免疫学比较。在粉状饮食条件下，SUS大鼠的菌斑积聚与免疫球蛋白水平显著高于RES大鼠有关，尤其是血清IgG和IgM。年轻（小于9周）的SUS大鼠的脾脏T淋巴细胞比年轻的RES大鼠少。这种减少与体外脾细胞对T细胞有丝分裂原Con A和PHA的反应显著降低有关。这种减少与饮食无关，并且在成年（3个月）大鼠中完全自发逆转。这些研究表明，大量菌斑的积聚导致免疫球蛋白水平升高。然而，SUS大鼠中的菌斑积聚似乎并非继发于任何可证实的免疫异常。
