免疫球蛋白Fc部分对T淋巴细胞的激活。

Activation of T lymphocytes by the Fc portion of immunoglobulin.

作者信息

Thoman M L, Morgan E L, Weigle W O

出版信息

J Supramol Struct. 1980;13(4):479-88. doi: 10.1002/jss.400130407.

DOI:10.1002/jss.400130407

Abstract

T lymphocytes are stimulated to release T-cell-replacing factors in response to Fc fragments of human IgG, Lyt 1+23- T cells are directly triggered to factor production by Fc subfragments, derived from intact Fc fragments by macrophage-dependent enzymatic cleavage. These factor(s) replace T cell function in two Fc-mediated immune responses; induction of polyclonal antibody synthesis, and potentiation of anti-SRBC responses.

摘要

T淋巴细胞受到人IgG的Fc片段刺激后会释放T细胞替代因子，Lyt 1+23- T细胞会被巨噬细胞依赖性酶切从完整Fc片段衍生而来的Fc亚片段直接触发产生因子。这些因子在两种Fc介导的免疫反应中替代T细胞功能：诱导多克隆抗体合成以及增强抗绵羊红细胞反应。

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Activation of T lymphocytes by the Fc portion of immunoglobulin.免疫球蛋白Fc部分对T淋巴细胞的激活。

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2

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Enhancement of T. lymphocyte functions by Fc fragments of immunoglobulin. II. Augmentation of the cell-mediated lympholysis response occurs through an Lyt-1+2- helper T cell.免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。II. 通过Lyt-1+2-辅助性T细胞增强细胞介导的淋巴细胞溶解反应。

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引用本文的文献

1

Potentiation of specific human in vitro immune responses by the Fc portion of human immunoglobulin.人免疫球蛋白Fc部分对特定人体外免疫反应的增强作用。

Clin Exp Immunol. 1983 Aug;53(2):505-11.

2

Isolation and identification of a biologically active peptide derived from the CH3 domain of human IgG1.源自人IgG1 CH3结构域的一种生物活性肽的分离与鉴定

Proc Natl Acad Sci U S A. 1982 Sep;79(17):5388-91. doi: 10.1073/pnas.79.17.5388.

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