免疫球蛋白Fc部分对T淋巴细胞的激活。
Activation of T lymphocytes by the Fc portion of immunoglobulin.
作者信息
Thoman M L, Morgan E L, Weigle W O
出版信息
J Supramol Struct. 1980;13(4):479-88. doi: 10.1002/jss.400130407.
PMID:6971961
Abstract
T lymphocytes are stimulated to release T-cell-replacing factors in response to Fc fragments of human IgG, Lyt 1+23- T cells are directly triggered to factor production by Fc subfragments, derived from intact Fc fragments by macrophage-dependent enzymatic cleavage. These factor(s) replace T cell function in two Fc-mediated immune responses; induction of polyclonal antibody synthesis, and potentiation of anti-SRBC responses.
摘要
T淋巴细胞受到人IgG的Fc片段刺激后会释放T细胞替代因子，Lyt 1+23- T细胞会被巨噬细胞依赖性酶切从完整Fc片段衍生而来的Fc亚片段直接触发产生因子。这些因子在两种Fc介导的免疫反应中替代T细胞功能：诱导多克隆抗体合成以及增强抗绵羊红细胞反应。
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