Vianna N J, Polan A K
Ann Intern Med. 1978 Oct;89(4):550-6. doi: 10.7326/0003-4819-89-4-550.
A relatively common viral agent of low virulence and infectivity might be of etiologic importance in Hodgkin's disease. Age at initial exposure is a major determinant of the outcome of infection (immunity versus clinical disease) and the different epidemiologic patterns for this lymphoma observed internationally. Early exposure, particularly when it occurs in persons from high birth ranks, is associated with a relatively durable immunity. In contrast a delay in initial exposure, also mediated by family factors, results in higher clinical disease-to-immunity ratio. The large male excess in childhood Hodgkin's disease might be due to some sex-linked environmental factor operating early in life and the greater frequency of an asymptomatic carrier state in this sex.
一种毒力和传染性较低的相对常见病毒因子可能在霍奇金病的病因学中具有重要意义。初次接触时的年龄是感染结果（免疫与临床疾病）以及国际上观察到的这种淋巴瘤不同流行病学模式的主要决定因素。早期接触，尤其是发生在出生顺序较高的人群中时，与相对持久的免疫力相关。相反，初次接触的延迟，同样由家庭因素介导，会导致临床疾病与免疫的比例更高。儿童霍奇金病中男性明显多于女性，这可能是由于某种与性别相关的环境因素在生命早期起作用，以及该性别中无症状携带者状态的频率更高。
