Jones E L, Craver J M, Hurst J W, Bradford J A, Bone D K, Robinson P H, Cobbs B W, Thompkins T R, Hatcher C R
Ann Surg. 1981 Jun;193(6):733-42. doi: 10.1097/00000658-198106000-00008.
Patients having coronary bypass and aneurysm resection (N = 40) or aneurysm plication (N = 32) were compared with patients having coronary bypass without aneurysm (N = 2782). Unlike other series, the primary indication for surgery in the aneurysm patients was angina pectoris, with heart failure playing a secondary role. Multivessel disease was present in 83% of the patients with aneurysm. Total occlusion of the anterior descending coronary artery was more prevalent in the group of patients who had aneurysmectomy (75%) than in rhe group of patients who had plication (38%), and more grafts/patient could be performed in the plication group (2.6 vs 2.0). Location of the aneurysm was most often anteroapical (N = 55) and infrequently inferior (N = 6). Septal wall motion was akinetic or aneurysmal in 47% of the aneurysmectomy group, and 10% of the plication group. Postoperative requirements for inotropes or intra-aortic balloon assist was much higher in the aneurysm group (aneurysmectomy or plication) than in patients without aneurysm having bypass. Hospital mortality for aneurysm patients was 2.7% versus 1.4% in patients without aneurysms having coronary bypass. The actuarial survival rate at 42 months for all aneurysm patients was 90%. Improvement in anginal symptoms after plication and coronary bypass (96%) was more frequent than with aneurysmectomy and coronary bypass (76%) and this was attributed to larger viable muscle mass and greater revascularization. Although two-thirds of patients having surgery for aneurysms had improvement in heart failure symptoms after operation, 30% of those having aneurysmectomies and 35% of those having plications said they were unimproved after surgery. However, this could be explained by the finding that a significant number (35% of the aneurysmectomy and 45% of the plication group) were in heart failure Class I prior to operation. Hospital mortality has been progressively reduced and late survival increased by the surgical treatment of left ventricular aneurysm, primarily through early operation at a time when coronary bypass can be used as an adjunct to aneurysm resection or plication.
将接受冠状动脉搭桥术和动脉瘤切除术(N = 40)或动脉瘤折叠术(N = 32)的患者与未患动脉瘤而接受冠状动脉搭桥术的患者(N = 2782)进行比较。与其他系列研究不同,动脉瘤患者的主要手术指征是心绞痛,心力衰竭起次要作用。83%的动脉瘤患者存在多支血管病变。在接受动脉瘤切除术的患者组中,冠状动脉前降支完全闭塞更为常见(75%),而在接受折叠术的患者组中为38%,并且折叠术组每位患者能够进行更多的移植(2.6比2.0)。动脉瘤最常位于心尖前壁(N = 55),很少位于下壁(N = 6)。在动脉瘤切除术组中,47%的患者室间隔壁运动减弱或呈瘤样,折叠术组为10%。动脉瘤组(动脉瘤切除术或折叠术)术后对血管活性药物或主动脉内球囊辅助的需求远高于未患动脉瘤而接受搭桥术的患者。动脉瘤患者的医院死亡率为2.7%,而未患动脉瘤接受冠状动脉搭桥术的患者为1.4%。所有动脉瘤患者在42个月时的精算生存率为90%。折叠术联合冠状动脉搭桥术后心绞痛症状改善(96%)比动脉瘤切除术联合冠状动脉搭桥术更常见(76%),这归因于更大的存活肌肉量和更好的血运重建。虽然三分之二接受动脉瘤手术的患者术后心力衰竭症状有所改善,但30%接受动脉瘤切除术的患者和35%接受折叠术的患者表示术后未改善。然而,这可以通过以下发现来解释:相当数量(动脉瘤切除术组的35%和折叠术组的45%)在手术前处于心力衰竭I级。通过对左心室动脉瘤的手术治疗,医院死亡率已逐步降低,晚期生存率有所提高,主要是通过在冠状动脉搭桥术可作为动脉瘤切除或折叠术辅助手段时尽早进行手术。