Colasanti B K, Kosa J E, Trotter R R
Ann Ophthalmol. 1978 Aug;10(8):1067-74.
The responses of rabbit pupils to graded doses of both adrenergic and cholinergic drugs after chemical sympathectomy with 6-hydroxydopamine have been examined. For comparison, similar data were obtained in rabbits treated chronically with the norepinephrine synthesis inhibitor, alpha-methyl-para-tyrosine. While quantitative differences were apparent, the effects of these 2 treatments were qualitatively similar. In both cases, a marked reduction in the responsiveness of the iris to cholinergic agonists accompanied the development of supersensitivity to adrenergic amines.
研究了用6-羟基多巴胺进行化学交感神经切除术后，兔瞳孔对不同剂量肾上腺素能和胆碱能药物的反应。为作比较，还获取了长期用去甲肾上腺素合成抑制剂α-甲基-对-酪氨酸处理的兔的类似数据。虽然存在明显的定量差异，但这两种处理的效果在定性上相似。在这两种情况下，虹膜对胆碱能激动剂反应性的显著降低都伴随着对肾上腺素能胺超敏反应的出现。
