长期摄入亚临床剂量铅的大鼠的免疫反应。
Immune responses of rats chronically fed subclinical doses of lead.
作者信息
Bendich A, Belisle E H, Strausser H R
出版信息
Clin Exp Immunol. 1981 Jan;43(1):189-94.
Abstract
The effects of chronic feeding of low levels of lead on various cells of the rat immune system have been investigated. In the presence of Con A and PHA, lead appears to increase blastogenesis up to approximately 5 weeks with activity approaching that of the unleaded control cells at 14 weeks. B cells responded with increased mitogenicity in the presence of LPS up to the time of termination of the experiment (14 weeks). Macrophage activity and number in the lead-fed rat showed consistent decrease and eventual morphological impairment. It is hypothesized that lead has mitogen-like activity but disruption of macrophage-T cell interaction occurs with time.
摘要
已经研究了长期喂食低水平铅对大鼠免疫系统各种细胞的影响。在伴刀豆球蛋白A和植物血凝素存在的情况下，铅似乎会使细胞增殖反应增强，持续约5周，到14周时其活性接近未接触铅的对照细胞。在整个实验期间（14周），在脂多糖存在的情况下，B细胞的有丝分裂活性增强。喂食铅的大鼠体内巨噬细胞的活性和数量持续减少，最终出现形态损伤。据推测，铅具有类似促细胞分裂剂的活性，但随着时间的推移，巨噬细胞与T细胞之间的相互作用会受到破坏。
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