Tzehoval E, De Baetselier P, Feldman M, Segal S
Eur J Immunol. 1981 Apr;11(4):323-8. doi: 10.1002/eji.1830110411.
The control of the immunogenic antigen-presenting capacity of different subpopulations of thioglycollate-induced peritoneal macrophages had been investigated. The experiments revealed the existence of two major subpopulations of macrophages, only one of which was highly efficient in educating antigen-specific T cells. The other subpopulation, while highly phagocytic, was devoid of antigen-presenting capacity. Further analysis, using specific antisera directed at H-2I region gene products, revealed that the immunogenic antigen-presenting population expressed H-2I region-controlled membrane antigens. Searching for cellular elements which control the differentiation of this antigen-presenting macrophage subpopulation, it was found that its function was strictly controlled by T cells. T cell-deficient mice (nu/nu) failed to generate a functional antigen-presenting macrophage subpopulation. Transplantation of mature T lymphocytes to T cell-deprived mice restored the immunogenic function of their antigen-presenting macrophage subpopulation. Transplantation of mature T lymphocytes to T cell-deprived mice restored the immunogenic function of their antigen-presenting macrophages. The results obtained suggest the existence of heterogeneity of functions among macrophage subpopulations and add a new regulatory function for T cells.
已对巯基乙酸诱导的腹腔巨噬细胞不同亚群的免疫原性抗原呈递能力进行了研究。实验揭示了巨噬细胞存在两个主要亚群，其中只有一个亚群在教育抗原特异性T细胞方面效率很高。另一个亚群虽然吞噬能力很强，但缺乏抗原呈递能力。进一步使用针对H-2I区基因产物的特异性抗血清进行分析，发现具有免疫原性的抗原呈递群体表达H-2I区控制的膜抗原。在寻找控制该抗原呈递巨噬细胞亚群分化的细胞成分时，发现其功能受到T细胞的严格控制。T细胞缺陷小鼠（nu/nu）无法产生功能性抗原呈递巨噬细胞亚群。将成熟T淋巴细胞移植到T细胞缺乏的小鼠体内，可恢复其抗原呈递巨噬细胞亚群的免疫原性功能。将成熟T淋巴细胞移植到T细胞缺乏的小鼠体内，可恢复其抗原呈递巨噬细胞的免疫原性功能。所获得结果表明巨噬细胞亚群之间存在功能异质性，并为T细胞增添了一种新的调节功能。
