Rosenwasser L J, Rosenthal A S
J Immunol. 1979 Sep;123(3):1141-4.
The I region of the MHC appears to control antigen-specific macrophage-T lymphocyte interaction. The immune response to antigens such as Gl phi 9 are under control of two distinct I subregions, I-A and I-E/I-C. We have asked in a macrophage-dependent, antigen-specific murine T cell proliferation assay whether either or both gene products need be expressed in the antigen-presenting cells. We find that both Ir-Gl phi 9 alpha and beta genes must be expressed and function in the antigen-presenting cell.
主要组织相容性复合体（MHC）的I区似乎控制着抗原特异性巨噬细胞与T淋巴细胞的相互作用。对诸如谷氨酸脱氢酶9（Gl phi 9）等抗原的免疫反应受两个不同的I亚区，即I-A和I-E/I-C的控制。我们在一项依赖巨噬细胞的、抗原特异性的小鼠T细胞增殖试验中探究了抗原呈递细胞中是否需要表达一种或两种基因产物。我们发现Ir-Gl phi 9的α和β基因都必须在抗原呈递细胞中表达并发挥作用。
