体外被钥孔戚血蓝蛋白刺激的T淋巴细胞的辅助活性。
Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.
作者信息
Ward K N
出版信息
Immunology. 1981 May;43(1):111-6.
Details are given of a system for keyhole limpet haemocyanin (KLH)-induced DNA synthesis by murine T lymphocytes in vitro. Lymph node T cells from mice primed with KLH and Bordetella pertussis were stimulated with KLH under the defined conditions, and it was found that such cultured cells exhibited substantial non-specific helper activity. In contrast similarly primed T cells which had not been cultured showed only antigen-specific help. It is concluded that proper account should be taken of non-specific effects when studying the activity of antigen-specific helper cells in in vitro.
本文详细介绍了一种在体外由匙孔血蓝蛋白（KLH）诱导小鼠T淋巴细胞进行DNA合成的系统。用KLH和百日咳博德特氏菌致敏的小鼠的淋巴结T细胞在特定条件下用KLH刺激，结果发现这些培养的细胞表现出大量非特异性辅助活性。相比之下，未经培养的同样致敏的T细胞仅表现出抗原特异性辅助作用。得出的结论是，在体外研究抗原特异性辅助细胞的活性时，应适当考虑非特异性效应。
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