Suppr超能文献

体外被钥孔戚血蓝蛋白刺激的T淋巴细胞的辅助活性。

Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.

作者信息

Ward K N

出版信息

Immunology. 1981 May;43(1):111-6.

PMID:6972901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555193/
Abstract

Details are given of a system for keyhole limpet haemocyanin (KLH)-induced DNA synthesis by murine T lymphocytes in vitro. Lymph node T cells from mice primed with KLH and Bordetella pertussis were stimulated with KLH under the defined conditions, and it was found that such cultured cells exhibited substantial non-specific helper activity. In contrast similarly primed T cells which had not been cultured showed only antigen-specific help. It is concluded that proper account should be taken of non-specific effects when studying the activity of antigen-specific helper cells in in vitro.

摘要

本文详细介绍了一种在体外由匙孔血蓝蛋白（KLH）诱导小鼠T淋巴细胞进行DNA合成的系统。用KLH和百日咳博德特氏菌致敏的小鼠的淋巴结T细胞在特定条件下用KLH刺激，结果发现这些培养的细胞表现出大量非特异性辅助活性。相比之下，未经培养的同样致敏的T细胞仅表现出抗原特异性辅助作用。得出的结论是，在体外研究抗原特异性辅助细胞的活性时，应适当考虑非特异性效应。

相似文献

1
Helper activity of T lymphocytes which have been stimulated by keyhole limpet haemocyanin in vitro.体外被钥孔戚血蓝蛋白刺激的T淋巴细胞的辅助活性。
Immunology. 1981 May;43(1):111-6.
2
Helper activity of T cells stimulated in long-term culture.长期培养中受刺激的T细胞的辅助活性。
Eur J Immunol. 1979 Sep;9(9):671-80. doi: 10.1002/eji.1830090904.
3
In vitro immunization to KLH. II. Limiting dilution analysis of antigen-reactive cells in primary and secondary culture.
J Immunol. 1983 Jan;130(1):29-32.
4
Suppression of antigen-specific T cell responses by Leishmania major excreted factor: inhibition of activation signals linked to the T cell antigen receptor and interleukin 2 receptor.
Isr J Med Sci. 1994 Sep;30(9):673-9.
5
Non-specific immunosuppressive effects of mouse spleen extracts in vitro.
Immunology. 1979 May;37(1):61-7.
6
IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.白细胞介素-12作为一种佐剂，可促进辅助性T细胞1的生成，但不会抑制辅助性T细胞2的回忆反应。
J Immunol. 1996 Feb 1;156(3):887-94.
7
Augmentation of the antibody response by antigen-specific glycosylation-enhancing factor.
J Immunol. 1987 Apr 15;138(8):2561-7.
8
Antigen-specific and nonspecific mediators of T cell/B cell cooperation. IV. Development of a model system demonstrating responsiveness of two T cell functions to HGG in vitro.T细胞/B细胞协作的抗原特异性和非特异性介质。IV. 一个模型系统的建立，该系统证明了两种T细胞功能在体外对人丙种球蛋白（HGG）的反应性。
J Immunol. 1976 Nov;117(5 Pt.2):1953-9.
9
Formation of IgE-binding factors by rat T lymphocytes. V. Effect of adjuvant for the priming immunization on the nature of IgE binding factors formed by antigenic stimulation.大鼠T淋巴细胞产生IgE结合因子。V. 初次免疫佐剂对抗抗原刺激产生的IgE结合因子性质的影响。
J Immunol. 1982 Oct;129(4):1384-90.
10
In vitro production of antigen-specific T cells from unprimed mice: role of dexamethasone and anti-IL-10 antibodies.
Cell Immunol. 1997 Jun 15;178(2):187-96. doi: 10.1006/cimm.1997.1134.

引用本文的文献

1
Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model.糖缀合物疫苗在小鼠过继性淋巴细胞转移模型中诱导的免疫记忆。
Infect Immun. 1998 May;66(5):2026-32. doi: 10.1128/IAI.66.5.2026-2032.1998.

本文引用的文献

1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins.三硝基苯基-血蓝蛋白的免疫原性：一级和二级抗半抗原沉淀素的产生
J Immunol. 1966 Sep;97(3):421-30.
3
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.
4
Macrophage-lymphocyte interaction in the antigen-induced blastogenic response of human peripheral blood leukocytes.巨噬细胞与淋巴细胞在人外周血白细胞抗原诱导的增殖反应中的相互作用。
J Immunol. 1968 Jun;100(6):1184-94.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
Synergistic interaction of macrophages and lymphocytes in antigen-induced transformation of lymphocytes.巨噬细胞与淋巴细胞在抗原诱导的淋巴细胞转化中的协同相互作用。
J Exp Med. 1970 Jul 1;132(1):44-65. doi: 10.1084/jem.132.1.44.
7
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
8
Immune responses in vitro. I. Culture conditions for antibody synthesis.体外免疫反应。I. 抗体合成的培养条件。
Cell Immunol. 1972 Feb;3(2):264-76. doi: 10.1016/0008-8749(72)90165-7.
9
Antigen-induced deoxyribonucleic acid synthesis in mouse lymphocytes. II. Analysis of the cell populations required for and responding to antigen stimulation in vitro.
J Immunol. 1973 Oct;111(4):1176-82.
10
Synergy among lymphoid cells mediating the graft-versus-host response. 3. Evidence for interaction between two types of thymus-derived cells.介导移植物抗宿主反应的淋巴细胞间的协同作用。3. 两类胸腺来源细胞间相互作用的证据。
J Exp Med. 1972 Apr 1;135(4):764-79. doi: 10.1084/jem.135.4.764.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验